Philipp Yu
Technische Universität München
10 Papers
9 Citations
Philipp Yu is an academic researcher from Technische Universität München. The author has contributed to research in topics: Inflammation & Mutation (genetic algorithm). The author has an hindex of 5, co-authored 10 publications.
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Papers
An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice
Johannes Grosse,Attila Braun,David Varga-Szabo,Niklas Beyersdorf,Boris Schneider,Lutz Zeitlmann,Petra Hanke,Patricia Schropp,Silke Mühlstedt,Carolin N. Zorn,Michael Huber,Carolin Schmittwolf,Wolfgang Jagla,Philipp Yu,Thomas Kerkau,Harald Schulze,Michael Nehls,Bernhard Nieswandt +17 more
TL;DR: This work identifies Stim1 as a central regulator of platelet function and suggests a cell type-specific activation or composition of the CRAC complex in T cells, whose function is not well understood.
Autoimmunity and Inflammation Due to a Gain-of-Function Mutation in Phospholipase Cγ2 that Specifically Increases External Ca2+ Entry
Philipp Yu,Rainer Constien,Neil Dear,Matilda Katan,Petra Hanke,Tom D. Bunney,Sandra Kunder,Leticia Quintanilla-Martinez,Ulrike Huffstadt,Andreas Schröder,Neil P. Jones,Thomas Peters,Helmut Fuchs,Martin Hrabé de Angelis,Michael Nehls,Johannes Grosse,Philipp Wabnitz,Thomas H. Meyer,Kei Yasuda,Matthias Schiemann,Christian Schneider-Fresenius,Wolfgang Jagla,Andreas Russ,Andreas Popp,Michelle Josephs,Andreas Marquardt,Jürgen Laufs,Carolin Schmittwolf,Hermann Wagner,Klaus Pfeffer,Geert C. Mudde +30 more
TL;DR: This mutant identifies Plcg2 as a key regulator in an autoimmune and inflammatory disease mediated by B cells and non-B, non-T haematopoietic cells and emphasizes that by distinct genetic modulation, a single point mutation can lead to a complex immunological phenotype.
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Association study with Wegener granulomatosis of the human phospholipase Cγ2 gene
TL;DR: This report does not reveal any hints for an involvement of the PLCγ-2 gene in the pathogenesis of WG in the case-control study.
Patent
Modified phospholipase c-gamma-2, expression products, and non-human animal models comprising said genes, and therapeutic uses
Rainer Constien,Petra Hanke,Geert C. Mudde,Andreas Schroeder,Philipp Yu +4 more
- 01 Sep 2003
TL;DR: In this article, a nucleic acid sequence encoding a novel mutant PLC-2 protein which, when expressed in a mammal, was capable of enhancing the inflammation response and suppressing male fertility.
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