Philipp Ludin
Swiss Tropical and Public Health Institute
7 Papers
73 Citations
Philipp Ludin is an academic researcher from Swiss Tropical and Public Health Institute. The author has contributed to research in topics: Pentamidine & Aminopurine. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Philipp Ludin include University of Basel & University of Bern.
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Papers
The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets
Christelle Godel,Sujai Kumar,Georgios Koutsovoulos,Philipp Ludin,Daniel Nilsson,Francesco Comandatore,Nicola Wrobel,Marian Thompson,Christoph D. Schmid,Susumu Goto,Frédéric Bringaud,Adrian J. Wolstenholme,Claudio Bandi,Christian Epe,Ronald Kaminsky,Mark Blaxter,Pascal Mäser +16 more
TL;DR: The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets, and the differential presence of anabolic pathways such as heme and nucleotide biosynthesis hints at the intricate metabolic interrelationship between the heartworms and Wolbachia.
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs
Jane C. Munday,Anthonius A. Eze,Anthonius A. Eze,Nicola Baker,Lucy Glover,Caroline Clucas,David Aguinaga Andrés,Manal J. Natto,Ibrahim A. Teka,Jennifer McDonald,Rebecca S. Lee,Fabrice E. Graf,Fabrice E. Graf,Philipp Ludin,Philipp Ludin,Richard Burchmore,C. Michael R. Turner,Andy Tait,Annette MacLeod,Pascal Mäser,Pascal Mäser,Michael P. Barrett,David Horn,Harry P. de Koning +23 more
TL;DR: TbA QP2 mediates high-affinity uptake of pentamidine and melaminophenyl arsenicals in trypanosomes and TbAQP2 encodes the previously reported HAPT1 activity, which establishes Tb aQP 2 as an important drug transporter.
Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol
Fabrice E. Graf,Philipp Ludin,Philipp Ludin,Tanja Wenzler,Tanja Wenzler,Marcel Kaiser,Marcel Kaiser,Reto Brun,Reto Brun,Patient Pati Pyana,Philippe Büscher,Harry P. de Koning,David Horn,Pascal Mäser,Pascal Mäser +14 more
TL;DR: Two different kinds of TbAQP2 mutations found in T. b.
Genome-wide identification of molecular mimicry candidates in parasites.
TL;DR: To the authors' knowledge, this is the first genome-wide survey for molecular mimicry proteins in parasites, and can be adopted to any pair of host and pathogen, once appropriate negative control organisms are chosen.
In silico prediction of antimalarial drug target candidates.
TL;DR: The identified candidates from P. falciparum provide insight into biochemical peculiarities and vulnerable points of the malaria parasite and might serve as starting points for rational drug discovery.
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