Philipp Knopf
Siemens
10 Papers
3 Citations
Philipp Knopf is an academic researcher from Siemens. The author has contributed to research in topics: Internal medicine & Chemistry. The author has an hindex of 3, co-authored 5 publications.
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Papers
Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy.
Marieke F. Fransen,Mark J A Schoonderwoerd,Philipp Knopf,Marcel Camps,Lukas J. A. C. Hawinkels,Manfred Kneilling,Manfred Kneilling,Thorbald van Hall,Ferry Ossendorp +8 more
TL;DR: Preclinical data advocate for enrolling patients with their tumor-draining lymph nodes still in place, to optimally engage the antitumor immune response and thereby enhance clinical benefit.
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GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cells.
Christian Seitz,Sarah Schroeder,Philipp Knopf,Ann-Christin Krahl,Jana Hau,Sabine Schleicher,Manuela Martella,Leticia Quintanilla-Martinez,Manfred Kneilling,Bernd J. Pichler,Bernd J. Pichler,Peter Lang,Daniel Atar,Karin Schilbach,Rupert Handgretinger,Rupert Handgretinger,Patrick Schlegel,Patrick Schlegel +17 more
TL;DR: The data strongly support previous findings of GD2 as a BCSC-associated antigen and should be considered a promising novel approach for GD2-positive breast cancer, especially to eliminate disseminated tumor cells and prevent metastasis formation.
82
Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors
Philipp Knopf,Dimitri Stowbur,Sabrina H. L. Hoffmann,Natalie Hermann,Andreas Maurer,Valentina Bucher,Marilena Poxleitner,Bredi Tako,Dominik Sonanini,Balaji Krishnamachary,Sanhita Sinharay,Birgit Fehrenbacher,Irene González-Menéndez,Felix Reckmann,David Bomze,Lukas Flatz,Daniela Kramer,Martin Schaller,S. Forchhammer,Zaver M. Bhujwalla,Leticia Quintanilla-Martinez,Klaus Schulze-Osthoff,Mark Pagel,Marieke F. Fransen,Martin Röcken,André F. Martins,Bernd J. Pichler,K. Ghoreschi,Manfred Kneilling +28 more
TL;DR: It is demonstrated that acidosis, a common characteristic of solid tumors, significantly increases IFN-γ-induced PD-L1 expression on aggressive cancer cells, thus promoting immune escape and representing a previously unknown immune escape mechanism that may serve as a novel biomarker for anti-PD-L1/PD-1 treatment response.
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Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.
Johannes Schwenck,Johannes Schwenck,Andreas Maurer,Andreas Maurer,Birgit Fehrenbacher,Roman Mehling,Philipp Knopf,Natalie Mucha,Dennis Haupt,Kerstin Fuchs,Christoph M. Griessinger,Daniel Bukala,Julia Holstein,Martin Schaller,Irene Gonzalez Menendez,Kamran Ghoreschi,Kamran Ghoreschi,Leticia Quintanilla-Martinez,Michael Gütschow,Stefan Laufer,Thomas Reinheckel,Thomas Reinheckel,Martin Röcken,Hubert Kalbacher,Bernd J. Pichler,Bernd J. Pichler,Manfred Kneilling,Manfred Kneilling +27 more
TL;DR: Topically applied cathepsin B inhibitors might effectively limit DTHR such as contact dermatitis or psoriasis, as a complementary role for these two cysteine-type proteases is suggested.
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PET/MRI and Bioluminescent Imaging Identify Hypoxia as a Cause of Programmed Cell Death Ligand 1 Image Heterogeneity.
Katie M. Parkins,Balaji Krishnamachary,Desmond Jacob,Samata Kakkad,Meiyappan Solaiyappan,Akhilesh Mishra,Yelena Mironchik,Marie-France Penet,Michael T. McMahon,Philipp Knopf,Bernd J. Pichler,Sridhar Nimmagadda,Zaver M. Bhujwalla +12 more
TL;DR: In this paper , the authors examined the association between hypoxia and programmed cell death ligand 1 (PD-L1) expression using bioluminescence imaging (BLI) and PET/MRI in a syngeneic mouse model of triple-negative breast cancer (TNBC).
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