Philipp Buchgraber
Max Planck Society
7 Papers
5 Citations
Philipp Buchgraber is an academic researcher from Max Planck Society. The author has contributed to research in topics: Berkelic acid & Chemistry. The author has an hindex of 4, co-authored 4 publications.
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Papers
A Synthesis-Driven Structure Revision of Berkelic Acid Methyl Ester†
Philipp Buchgraber,Thomas N. Snaddon,Cornelia Wirtz,Richard Mynott,Richard Goddard,Alois Fürstner +5 more
TL;DR: Investigations on berkelic acid methyl ester suggest that the original structure assignment needs to be revised, and preliminary activity and selectivity data are highly encouraging.
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Total Synthesis of Berkelic Acid
Thomas N. Snaddon,Philipp Buchgraber,Saskia Schulthoff,Cornelia Wirtz,Richard Mynott,Alois Fürstner +5 more
TL;DR: A productive total synthesis of both enantiomers of berkelic acid is outlined that takes the structure revision of this bioactive fungal metabolite previously proposed by the group into account, which clearly surpasses the classical Ireland-Claisen procedure in terms of diastereoselectivity.
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New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.
Alexandros Vakalopoulos,Frank Wunder,Ingo Hartung,Gorden Redlich,Rolf Jautelat,Philipp Buchgraber,Jorma Hassfeld,Alexey Gromov,Niels Lindner,Donald Bierer,J. Gries,Walter Kroh,Holger Paulsen,Joachim Mittendorf,Dieter Lang,Eva-Maria Becker-Pelster,Damian Brockschnieder,Volker Geiss,Volkhart Min-Jian Li,Alexander Straub,Andreas Knorr,Thomas Mondritzki,H Trübel,Marian Raschke,Dirk Thomas,Peter Sandner,Johannes-Peter Stasch,Markus Follmann +27 more
TL;DR: In this article , the authors describe the identification, chemical optimization, and preclinical characterization of novel soluble guanylate cyclase (sGC) stimulators, and report the ultrahigh-throughput (uHTS)-based discovery of a new class of sGC stimulators from an imidazo[1,2-a]pyridine lead series.
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Synthesis-driven mapping of the dictyodendrin alkaloids
Philipp Buchgraber,Mathias M. Domostoj,Bodo Scheiper,Cornelia Wirtz,Richard Mynott,Jörg Rust,Alois Fürstner +6 more
TL;DR: It is demonstrated that the individual dictyodendrins and analogues are capable of cleaving double stranded DNA under oxidative conditions, provided that they exhibit at least one unprotected phenol group in their periphery.