Philip Gribbon
Fraunhofer Society
103 Papers
529 Citations
Philip Gribbon is an academic researcher from Fraunhofer Society. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 19, co-authored 65 publications. Previous affiliations of Philip Gribbon include Pfizer & GlaxoSmithKline.
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Papers
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Sebastian Günther,P. Reinke,Yaiza Fernández-García,J. Lieske,Thomas J. Lane,Helen M. Ginn,Faisal Hammad Mekky Koua,Christiane Ehrt,W. Ewert,Dominik Oberthuer,Oleksandr Yefanov,S. Meier,Kristina Lorenzen,Boris Krichel,Janine-Denise Kopicki,Luca Gelisio,W. Brehm,Ilona Dunkel,B. Seychell,Henry Gieseler,Brenna Norton-Baker,Brenna Norton-Baker,Beatriz Escudero-Pérez,M. Domaracky,S. Saouane,A. Tolstikova,Thomas A. White,Anna Hänle,M. Groessler,Holger Fleckenstein,F. Trost,M. Galchenkova,Y. Gevorkov,Chufeng Li,Salah Awel,Ariana Peck,Miriam Barthelmess,Frank Schlünzen,P. Lourdu Xavier,N. Werner,H. Andaleeb,N. Ullah,Sven Falke,Vasundara Srinivasan,Bruno Alves Franca,M. Schwinzer,Hévila Brognaro,Cromarte Rogers,D. Melo,Joanna J. Zaitseva-Doyle,Juraj Knoska,Gisel E. Peña-Murillo,Aida Rahmani Mashhour,V. Hennicke,Pontus Fischer,Johanna Hakanpää,Jan Meyer,Philip Gribbon,Bernhard Ellinger,Maria Kuzikov,Markus Wolf,Andrea R. Beccari,Gleb Bourenkov,David von Stetten,Guillaume Pompidor,Isabel Bento,Saravanan Panneerselvam,Ivars Karpics,Thomas R. Schneider,Maria Garcia-Alai,Stephan Niebling,Christian M. Günther,C. Schmidt,Robin Schubert,Huijong Han,J. Boger,Diana C. F. Monteiro,Linlin Zhang,Xinyuanyuan Sun,J. Pletzer-Zelgert,J. Wollenhaupt,Christian G. Feiler,Manfred S. Weiss,Eike C. Schulz,Pedram Mehrabi,Katarina Karničar,Aleksandra Usenik,Jure Loboda,Henning Tidow,Ashwin Chari,Rolf Hilgenfeld,Charlotte Uetrecht,Russell J. Cox,Andrea Zaliani,Tobias Beck,Matthias Rarey,Stephan Günther,Dušan Turk,Winfried Hinrichs,Winfried Hinrichs,Henry N. Chapman,Arwen R. Pearson,Christian Betzel,Alke Meents +103 more
TL;DR: In this article, a high-throughput x-ray crystallographic screen of two repurposing drug libraries against the SARS-CoV-2 main protease (Mpro), which is essential for viral replication, was performed.
Macromolecular diffusion of biological polymers measured by confocal fluorescence recovery after photobleaching.
TL;DR: The confocal FRAP method provides a technique for investigating the macromolecular organization in glycan-rich networks at concentrations close to those found physiologically.
152
Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen
Maria Kuzikov,Elisa Costanzi,Jeanette Reinshagen,Francesca Esposito,Laura Vangeel,Markus Wolf,Bernhard Ellinger,Carsten Claussen,Gerd Geisslinger,Gerd Geisslinger,Angela Corona,Daniela Iaconis,Carmine Talarico,Candida Manelfi,Rolando Cannalire,Giulia Rossetti,Giulia Rossetti,Jonas Gossen,Simone Albani,Francesco Musiani,Katja Herzog,Yang Ye,Barbara Giabbai,Nicola Demitri,Dirk Jochmans,Steven De Jonghe,Jasper Rymenants,Vincenzo Summa,Enzo Tramontano,Andrea R. Beccari,Pieter Leyssen,Paola Storici,Johan Neyts,Philip Gribbon,Andrea Zaliani +34 more
- 11 Mar 2021
TL;DR: In this article, compound repurposing is an important strategy for the identification of effective treatment options against SARS-CoV-2 infection and COVID-19 disease and 3CL-2 main protease (3CL-...
128
The molecular basis of the solution properties of hyaluronan investigated by confocal fluorescence recovery after photobleaching.
TL;DR: Self and tracer lateral diffusion coefficients within hyaluronan solutions were measured over a wide range of concentrations (c), with varying electrolyte and at neutral and alkaline pH, consistent with a more dynamic and permeable network.
113
Alpha-1-acid (AAG, orosomucoid) glycoprotein: interaction with bacterial lipopolysaccharide and protection from sepsis.
TL;DR: The time course of AAG production in the acute phase response together with its strong affinity for basic compounds suggests that AAG may function as an immune modulator to bind both exogenous and endogenous inflammatory mediators.
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