Philip D. Stahl

TL;DR: The introduction of a quaternary ammonium cation to DAG molecules, using N-chlorobetainyl chloride, to afford a derivatized DAG that gives 2 orders of magnitude higher signal intensities than their underivatized sodium adducts is described.

TL;DR: It is concluded that Rab5-GTP is required on both sets of endosomes for docking and fusion of early endosome fusion in vitro and in living cells.

TL;DR: It is shown that mannose receptor, a very important conduit for internalization of infectious agents and self antigens, is functionally expressed in the murine CNS, and astrocytes and microglia were shown to be the prime cells expressing this receptor.

TL;DR: It is demonstrated that IL4 (a Th-2 cytokine) and prostaglandin E2 (PGE2) synergistically induce Rab5 and several Rab effector proteins, including Rin1 and EEA1, and promote the formation of an enlarged early endocytic (EEE) compartment, and it is speculated that the EEE is maintained by activated Rab5, and that theEEE phenotype is part of some macrophage developmental program such as cell fusion, a characteristic