Peter Würl
Leipzig University
77 Papers
1K Citations
Peter Würl is an academic researcher from Leipzig University. The author has contributed to research in topics: Soft tissue sarcoma & Sarcoma. The author has an hindex of 25, co-authored 76 publications. Previous affiliations of Peter Würl include University of Ulm.
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Papers
Increased survivin transcript levels: an independent negative predictor of survival in soft tissue sarcoma patients.
Matthias Kappler,Thomas Köhler,Christiane Kampf,Petra Diestelkötter,Peter Würl,Marc Schmitz,Frank Bartel,Christine Lautenschläger,Ernst Peter Rieber,Hannelore Schmidt,Matthias Bache,Helge Taubert,Axel Meye,Axel Meye +13 more
TL;DR: This work investigates the quantitative expression of survivin mRNA by a sensitive TaqMan™‐based RT‐PCR assay in tissue samples from 94 patients with soft tissue sarcomas (STS) and finds an inverse correlation between the level of Survivin mRNA and the rate of overall survival.
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Omeprazole Inhibits Proliferation and Modulates Autophagy in Pancreatic Cancer Cells
Andrej Udelnow,Andreas Kreyes,Stefan Ellinger,Katharina Landfester,Paul Walther,Thomas Klapperstueck,Johannes Wohlrab,Doris Henne-Bruns,Uwe Knippschild,Peter Würl +9 more
TL;DR: It is hypothesised that omeprazole interacts with the regulatory functions of the vATPase without inhibiting its pump function and a modulation of the lysosomal transport pathway and autophagy is caused in pancreatic cancer cells leading to programmed cell death.
Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma
Peter Würl,Matthias Kappler,Axel Meye,Frank Bartel,Thomas Köhler,Christine Lautenschläger,Matthias Bache,Hannelore Schmidt,Helge Taubert +8 more
TL;DR: Co-expression of survivin and TERT transcripts identifies patients at high risk of tumour-related death.
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Genomic imbalances of 7p and 17q in malignant peripheral nerve sheath tumors are clinically relevant.
Hannelore Schmidt,Peter Würl,Helge Taubert,Axel Meye,Matthias Bache,Hans-Jürgen Holzhausen,Raoul Hinze +6 more
TL;DR: In sporadic MPNSTs from patients with Recklinghausen's disease, the most frequent gains were narrowed down predominantly to 5p, 6, 8q, and 20q, whereas in MPN STs from Patients with Recklingshausen’s disease, there was most often a gain in 7q,8q, 15Q, and 17q.
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Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma.
Frank Bartel,Axel Meye,Peter Würl,Matthias Kappler,Matthias Bache,Christine Lautenschläger,Ulrich Grünbaum,Hannelore Schmidt,Helge Taubert +8 more
TL;DR: The MDM2 gene encodes a 90‐kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs) and was found to be more likely to be present in grade 1 tumors than in grade 2 or 3 tumors, and the presence of the spliced forms was associated with elevated levels of TP53.
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