Peter Van den Bossche
Institute of Tropical Medicine Antwerp
15 Papers
28 Citations
Peter Van den Bossche is an academic researcher from Institute of Tropical Medicine Antwerp. The author has contributed to research in topics: Population & Drug resistance. The author has an hindex of 12, co-authored 15 publications. Previous affiliations of Peter Van den Bossche include University of Pretoria.
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Papers
Molecular tools for the rapid detection of drug resistance in animal trypanosomes
TL;DR: The mechanisms involved in resistance to isometamidium and diminazene will be discussed, together with some new molecular detection tools that have been developed recently enabling faster diagnosis of drug resistance than conventional laboratory or field tests.
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High prevalence of drug resistance in animal trypanosomes without a history of drug exposure.
Simbarashe Chitanga,Simbarashe Chitanga,Tanguy Marcotty,Tanguy Marcotty,Boniface Namangala,Peter Van den Bossche,Peter Van den Bossche,Jan Van Den Abbeele,V. Delespaux +8 more
TL;DR: The widespread presence of the DA-resistance linked mutation in T. congolense isolated from wildlife suggests that this mutation is favourable to parasite survival and/or its dissemination in the host population independent from the presence of drug.
Five-fold increase in Trypanosoma congolense isolates resistant to diminazene aceturate over a seven-year period in eastern Zambia
V. Delespaux,Hunduma Dinka,Justin Masumu,Peter Van den Bossche,Peter Van den Bossche,Stanny Geerts +5 more
TL;DR: Two groups of Trypanosoma congolense isolates collected from cattle in Zambia were analyzed by BclI-PCR-RFLP to assess the evolution of diminazene aceturate (DA) resistance and it is suggested that genetic exchange of resistance genes might explain the increased frequency of resistance to DA.
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Adaptations in the Glucose Metabolism of Procyclic Trypanosoma brucei isolates from tsetse flies and during differentiation of bloodstream forms.
Koen W. A. van Grinsven,Jan Van Den Abbeele,Peter Van den Bossche,Jaap J. van Hellemond,Aloysius G.M. Tielens,Aloysius G.M. Tielens +5 more
TL;DR: Procyclic forms of Trypanosoma brucei isolated from the midguts of infected tsetse flies, or freshly transformed from a strain that is close to field isolates, do not use a complete Krebs cycle, and short stumpy bloodstream forms produce acetate.
Improved PCR-RFLP for the Detection of Diminazene Resistance in Trypanosoma congolense under Field Conditions Using Filter Papers for Sample Storage
Hervé Sèna Vitouley,Erick O Mungube,Emmanuel Allegye-Cudjoe,O. Diall,Zakaria Bocoum,Boucader Diarra,Thomas F. Randolph,Burkhard Bauer,Peter-Henning Clausen,Dirk Geysen,Issa Sidibé,Zakaria Bengaly,Peter Van den Bossche,V. Delespaux +13 more
TL;DR: A BclI-PCR-RFLP was developed for the molecular diagnosis of DA resistance in T. congolense, the most widely used trypanocidal drug, and has been transferred to a network of regional reference laboratories in West, East, and Southern Africa for use in large-scale surveys.
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