Peter Spargo
Pfizer
18 Papers
237 Citations
Peter Spargo is an academic researcher from Pfizer. The author has contributed to research in topics: Cycloaddition & Dithiolane. The author has an hindex of 7, co-authored 18 publications. Previous affiliations of Peter Spargo include University of Sheffield.
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Papers
(1R,3R)-2-Methylene-1,3-dithiolane 1,3-dioxide: a highly reactive and highly selective chiral ketene equivalent in cycloaddition reactions with a broad range of dienes
TL;DR: The chiral ketene equivalent trans-2-methylene-1,3-dithiolane 1,3dioxide has been prepared in racemic and enantiomerically pure form in four steps as mentioned in this paper.
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Patent
Polymorphic and pseudopolymorphic forms of a pharmaceutical compound
Sisir Bhattacharya,Alain Bonnet,Mahendra G. Dedhiya,Véronique Ducandas,Alexandre Giuliani,Alain Priour,Valérie Ravaux,Peter Spargo +7 more
- 08 Oct 2010
TL;DR: In this paper, the sodium salt of (1R,2S,5R)-7-oxo-6-sulfooxy-1,6- diazabicyclo[3.2] octane-2-carboxamide in hydrated or anhydrous crystallized enantiomeric form and in particular in the novel crystallized polymorphic and pseudopolymorphic forms "A", "B", "D" and "E" defined in the application, as well as the method of preparation.
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Highly diastereoselective 1,3-dipolar cycloaddition reactions of trans-2-methylene-1,3-dithiolane 1,3-dioxide with 3-oxidopyridinium and 3-oxidopyrylium betaines: a route to the tropane skeleton.
Varinder K. Aggarwal,Richard S. Grainger,Gary Newton,Peter Spargo,Adrian D. Hobson,Harry Adams +5 more
TL;DR: The C2-symmetric vinyl sulfoxide, trans-2-methylene-1, 3-dithiolane 1,3-dioxide, was found to react with a range of 3-oxidopyridinium betaines (bearing different substituents on nitrogen) in high yield and with total diastereoselectivity.
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1,3-dipolar cycloaddition reactions of trans-2-methylene-1,3-dithiolane 1,3-dioxide with nitrones
TL;DR: In this paper, an asymmetric 1,3-dipolar cycloaddition reaction between a nitrone and an olefinic dipolarophile is described, which is an efficient method for the synthesis of the isoxazolidine ring system.
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