Peter Sisk
Broad Institute
3 Papers
Peter Sisk is an academic researcher from Broad Institute. The author has contributed to research in topics: Mycobacterium tuberculosis & Gene. The author has an hindex of 3, co-authored 3 publications. Previous affiliations of Peter Sisk include Stanford University.
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Papers
TB database: an integrated platform for tuberculosis research
T. B. K. Reddy,Robert Riley,Farrell Wymore,Phillip Montgomery,David DeCaprio,Reinhard Engels,Marcel Gellesch,Jeremy Hubble,Dennis Jen,Heng Jin,Michael Koehrsen,Lisa Larson,Maria Mao,Michael Nitzberg,Peter Sisk,Christian Stolte,Brian Weiner,Jared White,Zachariah K. Zachariah,Gavin Sherlock,James E. Galagan,Catherine A. Ball,Gary K. Schoolnik +22 more
TL;DR: The Tuberculosis Database (TBDB) is an integrated database providing access to TB genomic data and resources, relevant to the discovery and development of TB drugs, vaccines and biomarkers, and provides a unique discovery platform for TB research.
Genetic Determinants of Drug Resistance in Mycobacterium tuberculosis and Their Diagnostic Value.
Maha R. Farhat,Razvan Sultana,Oleg Iartchouk,Sam Bozeman,James E. Galagan,Peter Sisk,Christian Stolte,Hanna Nebenzahl-Guimaraes,Karen R. Jacobson,Alexander Sloutsky,Devinder Kaur,James E. Posey,Barry N. Kreiswirth,Natalia Kurepina,Leen Rigouts,Elizabeth M. Streicher,Tommie C. Victor,Robin M. Warren,Dick van Soolingen,Megan Murray +19 more
TL;DR: Data suggest that a comprehensive M. tuberculosis drug resistance diagnostic will need to allow for a high dimension of mutation detection and support the hypothesis that currently unknown genetic determinants, potentially discoverable by whole-genome sequencing, encode resistance to second-line tuberculosis drugs.
Comparative analysis of Mycobacterium and related Actinomycetes yields insight into the evolution of Mycobacterium tuberculosis pathogenesis
Abigail Manson McGuire,Brian Weiner,Sang Tae Park,Ilan Wapinski,Ilan Wapinski,Sahadevan Raman,Gregory Dolganov,Matthew W. Peterson,Robert Riley,Jeremy Zucker,Thomas Abeel,Thomas Abeel,Jared White,Peter Sisk,Christian Stolte,Mike Koehrsen,Robert T Yamamoto,Milena Iacobelli-Martinez,Matthew J Kidd,Andreia M Maer,Gary K. Schoolnik,Aviv Regev,James E. Galagan,James E. Galagan +23 more
TL;DR: A comparative analysis of protein evolution highlights gene families that are associated with the adaptation of environmental Mycobacteria to obligate pathogenesis, including fatty acid metabolism, DNA repair, and molybdopterin biosynthesis and reinforces recent findings suggesting that small noncoding RNAs are more common in Myc Cobacteria than previously expected.