Peter Nicholas
Children's Hospital of Philadelphia
4 Papers
Peter Nicholas is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Aplastic anemia & Medicine. The author has an hindex of 3, co-authored 4 publications.
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Papers
Somatic HLA Mutations Expose the Role of Class I-Mediated Autoimmunity in Aplastic Anemia and its Clonal Complications
Daria V. Babushok,Jamie L. Duke,Hongbo Xie,Natasha Stanley,Jamie Atienza,Nieves Perdigones,Peter Nicholas,Deborah Ferriola,Yimei Li,Hugh Huang,Wenda Ye,Jennifer J.D. Morrissette,Jane Kearns,David L. Porter,Gregory M. Podsakoff,Laurence C. Eisenlohr,Jaclyn A. Biegel,Jaclyn A. Biegel,Jaclyn A. Biegel,Stella T. Chou,Dimitrios Monos,Monica Bessler,Timothy S. Olson +22 more
TL;DR: The finding of recurrent HLAclass I mutations provides compelling evidence for a predominant HLA class I-driven autoimmunity in aAA, and establishes a novel link between aAA patients' immunogenetics and clonal evolution.
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The predictive value of PNH clones, 6p CN-LOH, and clonal TCR gene rearrangement for aplastic anemia diagnosis.
Yash B. Shah,Salvatore F. Priore,Yimei Li,Chi N. Tang,Peter Nicholas,Peter Kurre,Timothy S. Olson,Daria V. Babushok,Daria V. Babushok +8 more
TL;DR: In this paper, the authors proposed to distinguish acquired aplastic anemia (AA) from inherited bone marrow failure syndromes using three laboratory findings specific to the autoimmune pathogenesis of AA: paroxysmal nocturnal hemoglobinuria (PNH) clones, copy-number-neutral loss of heterozygosity in chromosome arm 6p (6p CN-LOH), and clonal T-cell receptor (TCR) γ gene rearrangement.
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Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes.
Caitlin Ritz,Caitlin Ritz,Wenzhao Meng,Natasha Stanley,Natasha Stanley,Miren L. Baroja,Chong Xu,Patrick Yan,Alexander C. Huang,Alexander C. Huang,Ryan Hausler,Peter Nicholas,Jian-Meng Fan,David B. Lieberman,Beatriz M. Carreno,Beatriz M. Carreno,Eline T. Luning Prak,Timothy S. Olson,Daria V. Babushok,Daria V. Babushok +19 more
TL;DR: Acquired aplastic anemia is a T-cell–mediated autoimmune bone marrow aplasia, without a known etiologic trigger, that can occur following vaccination and accompany graft dysfunction or aplastics anemia relapse.
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Clonal hematopoiesis in patients with dyskeratosis congenita.
Nieves Perdigones,Juan C. Perin,Irene Schiano,Peter Nicholas,Jaclyn A. Biegel,Philip J. Mason,Daria V. Babushok,Monica Bessler +7 more
TL;DR: The results indicate that clonal hematopoiesis is a common feature of Dyskeratosis congenita, and suggest that such somatic changes, though commonly expected to indicate malignancy, may lead to improved blood cell production or stem cell survival.