Peter N. Inglis
Simon Fraser University
9 Papers
59 Citations
Peter N. Inglis is an academic researcher from Simon Fraser University. The author has contributed to research in topics: Cilium & Intraflagellar transport. The author has an hindex of 9, co-authored 9 publications.
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Papers
The sensory cilia of Caenorhabditis elegans.
TL;DR: The biogenesis, distribution, structures, composition and general functions of C. elegans cilia are discussed and how this system is being used to provide molecular insights into various human ciliopathies, including Polycystic Kidney Disease and Bardet-Biedl Syndrome are highlighted.
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An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes.
Chunmei Li,Peter N. Inglis,Carmen C. Leitch,Evgeni Efimenko,Norann A. Zaghloul,Calvin A. Mok,Erica E. Davis,Nathan J. Bialas,Michael P. Healey,Elise Héon,Mei Zhen,Peter Swoboda,Nicholas Katsanis,Michel R. Leroux +13 more
TL;DR: It is demonstrated that the C. elegans MIP-T3 ortholog DYF-11 is an intraflagellar transport (IFT) protein that plays a critical role in assembling functional kinesin motor-IFT particle complexes.
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis
Corey L. Williams,Chunmei Li,Katarzyna Kida,Peter N. Inglis,Swetha Mohan,Lucie Semenec,Nathan J. Bialas,Rachel M. Stupay,Nansheng Chen,Oliver E. Blacque,Bradley K. Yoder,Michel R. Leroux +11 more
TL;DR: Eight proteins, defects in which are associated with Meckel-Gruber syndrome and nephronophthisis ciliopathies, work together as two functional modules at the transition zone to establish basal body/transition zone connections with the membrane and barricade entry of non-ciliary components into this organelle.
Functional Genomics of the Cilium, a Sensory Organelle
Oliver E. Blacque,Elliot A. Perens,Keith A. Boroevich,Peter N. Inglis,Chunmei Li,Adam Warner,Jaswinder Khattra,Robert A. Holt,Guangshuo Ou,Allan K. Mah,Sheldon J. McKay,Peter Huang,Peter Swoboda,Steve J.M. Jones,Marco A. Marra,David L. Baillie,Donald G. Moerman,Shai Shaham,Michel R. Leroux +18 more
TL;DR: These findings help define a ciliary transcriptome and suggest that DYF-13, an evolutionarily conserved protein, is a novel core IFT component required for cilia function.
The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.
Oliver E. Blacque,Chunmei Li,Peter N. Inglis,Muneer A. Esmail,Guangshuo Ou,Allan K. Mah,David L. Baillie,Jonathan M. Scholey,Michel R. Leroux +8 more
TL;DR: It is indicated that IFTA-1 is a novel IFT protein that is required for retrograde transport along ciliary axonemes in Caenorhabditis elegans.