Peter Millner
Leeds Teaching Hospitals NHS Trust
16 Papers
3 Citations
Peter Millner is an academic researcher from Leeds Teaching Hospitals NHS Trust. The author has contributed to research in topics: Enthesis & Medicine. The author has an hindex of 7, co-authored 15 publications.
Chat about Author
Papers
Evidence that tissue resident human enthesis γδT-cells can produce IL-17A independently of IL-23R transcript expression.
Richard Cuthbert,Abdulla Watad,Evangelos M. Fragkakis,Robert Dunsmuir,Peter Loughenbury,Almas Khan,Peter Millner,Adam Davison,Helena Marzo-Ortega,Helena Marzo-Ortega,Darren J. Newton,Charlie Bridgewood,Dennis McGonagle,Dennis McGonagle +13 more
TL;DR: Spinal entheseal V δ1 and Vδ2 subsets are tissue resident cells with inducible IL-17A production with evidence that the Vη1 subset does so independently of IL-23R expression, and Transcript profiles of both cell populations suggested tissue residency and immunomodulatory status.
128
Identification of myeloid cells in the human enthesis as the main source of local IL-23 production
Charlie Bridgewood,Abdulla Watad,Tobias Russell,Timothy M. Palmer,Helena Marzo-Ortega,Almas Khan,Peter Millner,Robert Dunsmuir,Abhay Rao,Peter Loughenbury,Miriam Wittmann,Richard Cuthbert,Dennis McGonagle +12 more
TL;DR: The human enthesis contains a CD14+ myeloid population that produces most of the inducible IL-23, IL-1β, TNF and CCL20 and this population has similar gene expression profile to the matched blood CD14+, but showed significantly lower CCR2 gene expression.
95
Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression
Abdulla Watad,Hannah Rowe,Tobias Russell,Qiao Zhou,Qiao Zhou,Lisa Anderson,Almas Khan,Robert Dunsmuir,Peter Loughenbury,Vishal Borse,Abhay Rao,Peter Millner,Nicola Luigi Bragazzi,Nicola Luigi Bragazzi,Howard Amital,Richard Cuhtbert,Miriam Wittmann,Miriam Wittmann,Kassem Sharif,Tony J. Kenna,Matthew A. Brown,Darren J. Newton,Charlie Bridgewood,Dennis McGonagle +23 more
TL;DR: Healthy human entheseal CD4+ and CD8- T cells exhibit regulatory characteristics and are predicted to exhibit antiviral reactivity with CD8+ T’cells expressing higher levels of transcripts suggestive of tissue residency.
78
The management gram-negative bacterial haematogenous vertebral osteomyelitis: a case series of diagnosis, treatment and therapeutic outcomes
TL;DR: The treatment of GNB HVO is often challenging because of unpredictable resistance patterns and limited published data on effective treatment regimens, so the need for prompt microbiological sampling and initiation of early appropriate antibiotic regime is highlighted.
31
SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis Insights.
Qiao Zhou,Qiao Zhou,Qiao Zhou,Jayakumar Vadakekolathu,Abdulla Watad,Kassem Sharif,Tobias Russell,Hannah Rowe,Almas Khan,Peter Millner,Peter Loughenbury,Abhay Rao,Robert Dunsmuir,Jake Timothy,Giovanni Damiani,Paolo D. Pigatto,Piergiorgio Malagoli,Giuseppe Banfi,Yasser M. El-Sherbiny,Charlie Bridgewood,Dennis McGonagle,Dennis McGonagle +21 more
TL;DR: In this article, the authors investigated spinal entheseal plasmacytoid dendritic cells (pDCs) toll-like receptor (TLR)-7 and 9 activation and therapeutic modulation, including JAK inhibition.