Peter Milev
New York University
13 Papers
1.1K Citations
Peter Milev is an academic researcher from New York University. The author has contributed to research in topics: Neurocan & Proteoglycan. The author has an hindex of 12, co-authored 13 publications.
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Papers
Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules.
Peter Milev,David R. Friedlander,Takeshi Sakurai,Laina Karthikeyan,M. Flad,Renée K. Margolis,Martin Grumet,Richard U. Margolis +7 more
TL;DR: The studies suggest that by binding to neural cell adhesion molecules, and possibly also by competing for ligands of the transmembrane phosphatase, phosphacan may play a major role in modulating neuronal and glial adhesion, neurite growth, and signal transduction during the development of the central nervous system.
Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue.
Martin Grumet,Peter Milev,Takeshi Sakurai,Laina Karthikeyan,Mario Bourdon,Renée K. Margolis,Richard U. Margolis +6 more
TL;DR: The results suggest that tenascin binds phosphacan and neurocan in vivo and that interactions between chondroitin sulfate proteoglycans andTenascin may play important roles in nervous tissue histogenesis, possibly by modulating signal transduction across the plasma membrane.
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Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican.
Peter Milev,Patrice Maurel,Atsuro Chiba,Markus Mevissen,Susanna Popp,Yu Yamaguchi,Renée K. Margolis,Richard U. Margolis +7 more
TL;DR: Striking and distinctive changes in the concentrations of the different members of this family of structurally related proteoglycans in developing brain, including changes in opposite directions for versican mRNA splice variants, indicate that the individual proteoglyCans and their isoforms probably serve unique functions during nervous tissue histogenesis.
225
High Affinity Binding and Overlapping Localization of Neurocan and Phosphacan/Protein-tyrosine Phosphatase-ζ/β with Tenascin-R, Amphoterin, and the Heparin-binding Growth-associated Molecule
Peter Milev,Atsuro Chiba,Monika Häring,Heikki Rauvala,Melitta Schachner,Barbara Ranscht,Renée K. Margolis,Richard U. Margolis +7 more
TL;DR: Differences in the interactions of neurocan and phosphacan with the two major members of the tenascin family of extracellular matrix proteins are revealed, and it is suggested that chondroitin sulfate proteoglycans play an important role in the binding and/or presentation of differentiation factors in the developing central nervous system.
213
TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-ζ/β, and N-CAM
TL;DR: Immunocytochemical studies of embryonic and early postnatal nervous tissue showed an overlapping localization of TAG-1/axonin-1 with all four of these ligands, further supporting the biological significance of their ability to interact in vitro.
209