Peter M. Edwards
University of British Columbia
6 Papers
74 Citations
Peter M. Edwards is an academic researcher from University of British Columbia. The author has contributed to research in topics: Catalysis & Alkylation. The author has an hindex of 4, co-authored 6 publications. Previous affiliations of Peter M. Edwards include Northeastern University.
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Papers
Kinase Scaffold Repurposing for Neglected Disease Drug Discovery: Discovery of an Efficacious, Lapatanib-Derived Lead Compound for Trypanosomiasis
Gautam Patel,Caitlin E. Karver,Ranjan Behera,Paul J. Guyett,Catherine Sullenberger,Peter M. Edwards,Norma Roncal,Kojo Mensa-Wilmot,Michael P. Pollastri +8 more
TL;DR: This work reports promising activity of analogues of 1, which provided an excellent starting point for optimization of the chemotype, and compound optimization that has led to synthesis of several potent 4-anilinoquinazolines, including NEU617, 23a, a highly potent, orally bioavailable inhibitor of trypanosome replication.
Catalytic Synthesis of Secondary Amine-Containing Polymers: Variable Hydrogen Bonding for Tunable Rheological Properties
Mitchell R. Perry,Tannaz Ebrahimi,Erin Morgan,Peter M. Edwards,Savvas G. Hatzikiriakos,Laurel L. Schafer +5 more
TL;DR: Aryl-substituted secondary amine-containing polymers can be readily incorporated to access variable hydrogen-bonding characteristics as discussed by the authors, and the effect of hydrogen bonding on the bulk properties of these polymers has been shown.
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Idioms and Reading Comprehension
TL;DR: This article conducted a study to determine whether idioms cause difficulty for children in reading and understanding of prose, and found no significant difference between the performance of boys and girls in the tests, except for the two groups containing the greatest number of idioms in the test items.
2
Titanium catalyzed synthesis of amines and N-heterocycles
Laurel L. Schafer,Manfred Manßen,Peter M. Edwards,Erica K. J. Lui,Samuel E. Griffin,Christine R. Dunbar +5 more
- 01 Jan 2020
TL;DR: Titanium is an earth abundant inexpensive early transition metal that has been used extensively in industrial polyolefin synthesis, but rarely applied toward the synthesis of fine chemicals as discussed by the authors, however, ligand modified reactivity remains poorly understood and the development of predictive tools for understanding how ligands influence electronic properties at the metal center will advance efforts to realize new catalytic reactions.
Early transition metal-catalyzed C–H alkylation: hydroaminoalkylation for Csp3–Csp3 bond formation in the synthesis of selectively substituted amines
TL;DR: This feature article discusses the various selectively substituted amines that can be accessed by hydroaminoalkylation, with a special focus on the development of early transition metal catalysts for their rapid, step and atom efficient assembly.