Peter Liu
Genentech
39 Papers
112 Citations
Peter Liu is an academic researcher from Genentech. The author has contributed to research in topics: Biology & Unfolded protein response. The author has an hindex of 19, co-authored 39 publications.
Chat about Author
Papers
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more
TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
3.1K
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
Robin A. Aglietti,Alberto Estevez,Aaron Gupta,Monica Gonzalez Ramirez,Peter Liu,Nobuhiko Kayagaki,Claudio Ciferri,Vishva M. Dixit,Erin C. Dueber +8 more
TL;DR: The mouse I105N/human I104N mutation, which has been shown to prevent macrophage pyroptosis, attenuated both cell killing by p30 in a 293T transient overexpression system and membrane permeabilization in vitro, suggesting that the mutants are actually hypomorphs, but must be above certain concentration to exhibit activity.
827
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain
Ben Chih,Peter Liu,Yvonne Chinn,Cecile Chalouni,László G. Kömüves,Philip E. Hass,Wendy Sandoval,Andrew S. Peterson +7 more
TL;DR: The complex that is described is essential for normal cilia function and acts as a diffusion barrier to maintain the cilia membrane as a compartmentalized signalling organelle.
378
Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling
Marinella Callow,Hoanh Tran,Lilian Phu,Ted Lau,James Lee,Wendy Sandoval,Peter Liu,Sheila Bheddah,Janet Tao,Jennie R. Lill,Jo-Anne Hongo,David M Davis,Donald S. Kirkpatrick,Paul Polakis,Mike Costa +14 more
TL;DR: RNF146, tankyrase, and Axin form a protein complex, and it is demonstrated that RNF146 mediates ubiquitylation of all three proteins to target them for proteasomal degradation.
The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins.
Kushal Suryamohan,Sajesh Puthenpurackal Krishnankutty,Joseph Guillory,Matthew Jevit,Markus S. Schröder,Meng Wu,Boney Kuriakose,Oommen K. Mathew,Rajadurai Chinnasamy Perumal,Ivan Koludarov,Leonard D. Goldstein,Kate Senger,Mandumpala Davis Dixon,Dinesh Velayutham,Derek Vargas,Subhra Chaudhuri,Megha Muraleedharan,Ridhi Goel,Ying Jiun J. Chen,Aakrosh Ratan,Peter Liu,Brendan Faherty,Guillermo de la Rosa,Hiroki Shibata,Miriam Baca,Meredith Sagolla,James Ziai,Gus A. Wright,Domagoj Vucic,Sangeetha Mohan,Aju Antony,Jeremy Stinson,Donald S. Kirkpatrick,Rami N. Hannoush,Steffen Durinck,Zora Modrusan,Eric Stawiski,Kristen Wiley,Terje Raudsepp,R. Manjunatha Kini,Arun Zachariah,Somasekar Seshagiri +41 more
TL;DR: The genome of Naja naja, the Indian cobra, a highly venomous, medically important snake, is reported, which could serve as a reference for snake genomes, support evolutionary studies and enable venom-driven drug discovery.