Peter L. Jeffrey
Children's Medical Research Institute
29 Papers
690 Citations
Peter L. Jeffrey is an academic researcher from Children's Medical Research Institute. The author has contributed to research in topics: Actin & Microfilament. The author has an hindex of 22, co-authored 29 publications. Previous affiliations of Peter L. Jeffrey include University of Sydney.
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Papers
Tropomyosin Localization Reveals Distinct Populations of Microfilaments in Neurites and Growth Cones
Galina Schevzov,Peter W. Gunning,Peter L. Jeffrey,Connie Temm-Grove,David M. Helfman,Jim J.-C. Lin,Ron P. Weinberger +6 more
TL;DR: It is concluded that the organization of Tm5NM1-2 and Tm 5a/5b in the neurite is at least partially dependent on microtubule integrity, and the composition of microfilaments differs between neurites and growth cones and is subject to temporal regulation.
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Survival of purified embryonic chick retinal ganglion cells in the presence of neurotrophic factors.
TL;DR: The results, obtained with a culture system which allowed the analysis of direct trophic actions, suggest that NGF and CNTF may be NTFs for overlapping subpopulations of chick RGCs.
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Sorting of tropomyosin isoforms in synchronised NIH 3T3 fibroblasts: evidence for distinct microfilament populations
Justin M. Percival,Gethin P. Thomas,Terri Anne Cock,Edith M. Gardiner,Peter L. Jeffrey,Jim J.-C. Lin,Ron P. Weinberger,Ron P. Weinberger,Peter W. Gunning,Peter W. Gunning +9 more
TL;DR: It is concluded that the expression and localisation of Tm isoforms are differentially regulated in G0 and G1 phase of the cell cycle and can be observed in human columnar epithelial cells in vivo.
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Creating intracellular structural domains: spatial segregation of actin and tropomyosin isoforms in neurons.
TL;DR: Developmental regulation of this isoform sorting suggests a specific role for some isoforms in growth and for others in stabilization of neuronal structure, providing a mechanism by which a neuron can create and independently regulate intracellular domains composed of microfilaments with different functional properties.
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Actin and tropomyosin isoforms in morphogenesis
TL;DR: It is now apparent that isoforms of these proteins perform different structural tasks and the challenge is to link the significance of spatial sorting to the different physicochemical properties of these isoforms.
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