Peter Krasnov
Cold Spring Harbor Laboratory
12 Papers
18 Citations
Peter Krasnov is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Stem cell & Biology. The author has an hindex of 9, co-authored 12 publications.
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Papers
p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.
Brandon M. Hall,Vitaly Balan,Anatoli S. Gleiberman,Evguenia Strom,Peter Krasnov,Lauren P. Virtuoso,Elena Rydkina,Slavoljub Vujcic,Karina Balan,Ilya Gitlin,Katerina I. Leonova,Camila Rosat Consiglio,Sandra O. Gollnick,Olga B. Chernova,Andrei V. Gudkov +14 more
- 02 Aug 2017
TL;DR: It is reported that expression of p 16Ink4a and SAβG in macrophages is acquired as part of a physiological response to immune stimuli rather than through senescence, consistent with reports that p16InK4a plays a role in Macrophage polarization and response.
Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
Brandon M. Hall,Vitaly Balan,Anatoli S. Gleiberman,Evguenia Strom,Peter Krasnov,Lauren P. Virtuoso,Elena Rydkina,Slavoljub Vujcic,Karina Balan,Ilya Gitlin,Katerina I. Leonova,Alexander Polinsky,Olga B. Chernova,Andrei V. Gudkov +13 more
- 06 Jul 2016
TL;DR: Old mice with elevated proportion of p16(Ink4a)/β-galpH6-positive cells in their tissues demonstrated reduction of both following systemic clodronate treatment, indicating that a significant proportion of cells previously considered to be SCs are actually a subclass of macrophages.
Nitric Oxide Is a Regulator of Hematopoietic Stem Cell Activity
Tatyana V. Michurina,Peter Krasnov,Alejandro B. Balazs,Naoki Nakaya,Tamara T. Vasilieva,B. A. Kuzin,B. A. Kuzin,Nikolay Khrushchov,Richard C. Mulligan,Grigori Enikolopov +9 more
TL;DR: It is shown that it is possible to increase the number of stem and progenitor cells in the bone marrow by suppressing the activity of NO synthases (NOS), and this indicates that NO is important for the control of hematopoietic stem Cells in the BM.
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Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2).
Alexander N. Shakhov,Vijay K. Singh,Frederick Bone,Alec Cheney,Yevgeniy Kononov,Peter Krasnov,Troitza K. Bratanova-Toshkova,Vera V. Shakhova,Jason A. Young,Michael M. Weil,Angela Panoskaltsis-Mortari,Christie M. Orschell,Patricia Stanhope Baker,Andrei V. Gudkov,Elena Feinstein +14 more
TL;DR: It is demonstrated that synthetic lipopeptides (sLP) that mimic the structure of naturally occurring mycoplasmal BLP significantly increase mouse survival following lethal total body irradiation (TBI) when administered between 48 hours before and 24 hours after irradiation.
The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates.
Vadim I. Krivokrysenko,Ilia Toshkov,Anatoli S. Gleiberman,Peter Krasnov,Inna Shyshynova,Ivan A. Bespalov,Ratan K. Maitra,Natalya V. Narizhneva,Vijay K. Singh,Mark H. Whitnall,Andrei Purmal,Alexander N. Shakhov,Andrei V. Gudkov,Elena Feinstein +13 more
TL;DR: Data from several exploratory studies conducted in lethally irradiated non-human primates treated with a single intramuscular injection of entolimod indicate that entolIMod is a highly promising potential life-saving treatment for victims of radiation disasters.