Peter J. Wirth
National Institutes of Health
60 Papers
1.3K Citations
Peter J. Wirth is an academic researcher from National Institutes of Health. The author has contributed to research in topics: 2-Acetylaminofluorene & Gene expression. The author has an hindex of 26, co-authored 60 publications.
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Papers
Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing.
Qi An Sun,Francesca Zappacosta,Valentina M. Factor,Peter J. Wirth,Dolph L. Hatfield,Vadim N. Gladyshev +5 more
TL;DR: A remarkable heterogeneity within TRs is demonstrated, which, at least in part, results from evolutionary conserved genetic mechanisms employing alternative first exon splicing.
100
•Journal Article
Mutagenic activation of N-hydroxy-2-acetylaminofluorene in the Salmonella test system: the role of deacetylation by liver and kidney fractions from mouse and rat.
TL;DR: The data indicate that deacetylation is the most important step in the mutagenic activation of N-hydroxy-2-acetylaminofluorene by mouse and rat liver and kidney fractions and that the arylnitrenium ion is the electrophilic species interacting with the bacterial DNA, resulting in the frameshift mutation.
98
Identification of gel-separated tumor marker proteins by mass spectrometry
Ann Charlotte Bergman,Timothy Benjamin,Ayodele Alaiya,Mark Waltham,Kazuyazu Sakaguchi,Bo Franzén,Stig Linder,Tomas Bergman,Gert Auer,Ettore Appella,Peter J. Wirth,Hans Jörnvall +11 more
TL;DR: The protein processing and the difference between protein and mRNA abundancies in tumors of different malignancy and origin suggest that studies at the protein level are important for an understanding of tumor phenotypes.
96
•Journal Article
Mechanism of in Vitro Mutagenic Activation and Covalent Binding of N-Hydroxy-2-acetylaminofluorene in Isolated Liver Cell Nuclei from Rat and Mouse
TL;DR: The in vitro mutagenic activation of N -hydroxy-2-acetylaminofluorene by isolated rat and mouse liver cell nuclei and the in vitro covalent binding of N-OH-AAF to nuclear nucleic acids and proteins were studied.
89
•Journal Article
Mechanism of N-hydroxyacetylarylamine mutagenicity in the Salmonella test system: metabolic activation of N-hydroxyphenacetin by liver and kidney fractions from rat, mouse, hamster, and man.
TL;DR: The data indicate that the initial step in the mutagenic activation of N-Hydroxyphenacetin in the Salmonella system proceeds via the same mechanism as that of the known carcinogen N-hydroxy-2-acetylaminofluorene.
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