Peter J. Hart
University of Birmingham
5 Papers
Peter J. Hart is an academic researcher from University of Birmingham. The author has contributed to research in topics: Salmonella typhi & Salmonella. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Peter J. Hart include Novartis & St George's, University of London.
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Papers
Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events
Vanessa K. Wong,Vanessa K. Wong,Stephen Baker,Stephen Baker,Stephen Baker,Derek Pickard,Julian Parkhill,Andrew J. Page,Nicholas A. Feasey,Robert A. Kingsley,Robert A. Kingsley,Nicholas R. Thomson,Nicholas R. Thomson,Jacqueline A. Keane,François-Xavier Weill,David J. Edwards,Jane Hawkey,Simon R. Harris,Alison E. Mather,Amy K. Cain,James Hadfield,Peter J. Hart,Nga Tran Vu Thieu,Elizabeth J. Klemm,Dafni A. Glinos,Robert F. Breiman,Robert F. Breiman,Robert F. Breiman,Conall H. Watson,Samuel Kariuki,Samuel Kariuki,Melita A. Gordon,Robert S. Heyderman,Chinyere K. Okoro,Jan Jacobs,Jan Jacobs,Octavie Lunguya,W. John Edmunds,Chisomo L. Msefula,José A. Chabalgoity,Mike Kama,Kylie Jenkins,Shanta Dutta,Florian Marks,Josefina Campos,Corinne N. Thompson,Corinne N. Thompson,Stephen K. Obaro,Calman A. MacLennan,Calman A. MacLennan,Calman A. MacLennan,Christiane Dolecek,Karen H. Keddy,Anthony M. Smith,Christopher M. Parry,Christopher M. Parry,Abhilasha Karkey,E. Kim Mulholland,James Campbell,James Campbell,Sabina Dongol,Buddha Basnyat,Muriel Dufour,Don Bandaranayake,Take Toleafoa Naseri,Shalini Singh,Mochammad Hatta,Paul N. Newton,Paul N. Newton,Robert S. Onsare,Lupeoletalalei Isaia,David A. B. Dance,David A. B. Dance,Viengmon Davong,Guy E. Thwaites,Guy E. Thwaites,Lalith Wijedoru,John A. Crump,Elizabeth de Pinna,Satheesh Nair,Eric J. Nilles,Duy Pham Thanh,Paul Turner,Paul Turner,Paul Turner,Sona Soeng,Mary Valcanis,Joan Powling,Karolina Dimovski,Geoff Hogg,Jeremy Farrar,Jeremy Farrar,Kathryn E. Holt,Gordon Dougan +93 more
TL;DR: This whole-genome sequence analysis of Salmonella enterica serovar Typhi identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years, and identifies numerous transmissions of H58.
Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen.
Peter J. Hart,Colette M. O’Shaughnessy,Matthew K. Siggins,Saeeda Bobat,Robert A. Kingsley,David Goulding,John A. Crump,Hugh Reyburn,Francesca Micoli,Gordon Dougan,Adam F. Cunningham,Calman A. MacLennan,Calman A. MacLennan,Calman A. MacLennan +13 more
TL;DR: Findings support a protective role for Vi capsule in preventing complement and phagocyte killing of Salmonella that can be overcome by specific anti-Vi antibodies, but only to a limited extent by anti-O:9 antibodies.
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Characterization of the yehUT Two-Component Regulatory System of Salmonella enterica Serovar Typhi and Typhimurium
Vanessa K. Wong,Derek Pickard,Lars Barquist,Karthikeyan Sivaraman,Andrew J. Page,Peter J. Hart,Mark J. Arends,Kathryn E. Holt,Leanne Kane,Lynda Mottram,Louise Ellison,Ruben Bautista,Chris J. McGee,Sally Kay,Thomas Wileman,Linda J. Kenney,Calman A. MacLennan,Robert A. Kingsley,Gordon Dougan +18 more
TL;DR: Growth, metabolic and antimicrobial susceptibility tests identified no obvious influences of yehUT on these phenotypes and deletion had no detectable effect on the ability of these mutant Salmonella to invade cultured epithelial cells.
Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa
Vanessa K. Wong,Vanessa K. Wong,Kathryn E. Holt,Chinyere K. Okoro,Chinyere K. Okoro,Stephen Baker,Stephen Baker,Derek Pickard,Florian Marks,Andrew J. Page,Grace Olanipekun,Huda Munir,Roxanne Alter,Paul D. Fey,Nicholas A. Feasey,François-Xavier Weill,Simon Le Hello,Peter J. Hart,Peter J. Hart,Samuel Kariuki,Samuel Kariuki,Robert F. Breiman,Robert F. Breiman,Robert F. Breiman,Melita A. Gordon,Melita A. Gordon,Robert S. Heyderman,Robert S. Heyderman,Jan Jacobs,Jan Jacobs,Octavie Lunguya,Chisomo L. Msefula,Chisomo L. Msefula,Calman A. MacLennan,Calman A. MacLennan,Calman A. MacLennan,Karen H. Keddy,Anthony M. Smith,Robert S. Onsare,Elizabeth de Pinna,Satheesh Nair,Ben Amos,Gordon Dougan,Stephen K. Obaro,Stephen K. Obaro,Stephen K. Obaro +45 more
TL;DR: Data indicate that typhoid in Nigeria was established through multiple independent introductions into the country, with evidence of regional spread, and MDR typhoid appears to be evolving independently of the haplotype H58 found in other typhoid endemic countries.
Identification of a common immune signature in murine and human systemic Salmonellosis
Seung-Joo Lee,Li Liang,Silvia Juarez,Minelva R. Nanton,Esther N. Gondwe,Chisomo L. Msefula,Matthew A. Kayala,Francesca Necchi,Francesca Necchi,Jennifer N. Heath,Peter J. Hart,Peter J. Hart,Renée M. Tsolis,Robert S. Heyderman,Robert S. Heyderman,Calman A. MacLennan,Calman A. MacLennan,Calman A. MacLennan,Philip L. Felgner,D. Huw Davies,Stephen J. McSorley +20 more
TL;DR: Together, these data uncover an overlapping immune signature of disseminated Salmonellosis in mice and humans and provide a foundation for the generation of a protective subunit vaccine.