Peter J. Feilen
University of Mainz
20 Papers
376 Citations
Peter J. Feilen is an academic researcher from University of Mainz. The author has contributed to research in topics: Transplantation & Pancreatic islets. The author has an hindex of 15, co-authored 20 publications.
Chat about Author
Papers
Fabrication of homogeneously cross-linked, functional alginate microcapsules validated by NMR-, CLSM- and AFM-imaging.
Heiko Zimmermann,M. Hillgärtner,Bertram Manz,Peter J. Feilen,Frank Brunnenmeier,Ulrich Leinfelder,M Weber,H. Cramer,Stephan Schneider,Christian Hendrich,Frank Volke,Ulrich Zimmermann +11 more
TL;DR: Encapsulation of rat islets, human monoclonal antibodies secreting hybridoma cells and murine mesenchymal stem cells transfected with cDNA encoding for bone morphogenetic protein revealed that injection of BaCl(2) crystals has no adverse side effects on cell viability and function, however, the release of low-molecular weight factors may be delayed when using alginate concentrations in the usual range.
100
Synthesis and evaluation of (S)-2-(2-[18F]fluoroethoxy)-4-([3-methyl-1-(2-piperidin-1-yl-phenyl)-butyl-carbamoyl]-methyl)-benzoic acid ([18F]repaglinide): a promising radioligand for quantification of pancreatic β-cell mass with positron emission tomography (PET)
B Wängler,Stephan Schneider,Oliver Thews,Esther Schirrmacher,S. Comagic,Peter J. Feilen,C. Schwanstecher,M. Schwanstecher,C-Y. Shiue,A. Alavi,S. Höhnemann,Markus Piel,Frank Rösch,Ralf Schirrmacher +13 more
TL;DR: Repaglinide induced a complete monophasic inhibition curve with a Hill coefficient close to 1 (1.03) yielding a dissociation constant ( K D ) of 134 nM, indicating that it might be suitable for in vivo investigation with PET.
55
Hepatocytes cultured in alginate microspheres: an optimized technique to study enzyme induction.
M. Ringel,M.-A. von Mach,Roberta Santos,Peter J. Feilen,Marc Brulport,Matthias Hermes,Alexander Bauer,Wiebke Schormann,Berno Tanner,Michael R. Schön,Franz Oesch,Jan G. Hengstler +11 more
TL;DR: The present study optimized an in vitro system with hepatocytes cultured in alginate microspheres that allows studies of enzyme induction with an improved sensitivity compared to existing systems and offers several technical advantages.
49
Size of pancreatic islets of Langerhans: a key parameter for viability after cryopreservation.
M.-A. von Mach,Josef Schlosser,Marcus Weiland,Peter J. Feilen,M. Ringel,Jan G. Hengstler,L. S. Weilemann,Jürgen Beyer,Peter H. Kann,Stephan Schneider +9 more
TL;DR: Large islets represented a highly susceptible population concerning damage due to cryopreservation, and different techniques of equilibration with the cryoprotectant resulted in significant changes of islet viability of medium islets, whereas small and large islets were unaffected.
38
Synthesis and in vitro evaluation of (S)-2-([11C]methoxy)-4-[3-methyl-1-(2-piperidine-1-yl-phenyl)-butyl-carbamoyl]-benzoic acid ([11C]methoxy-repaglinide): a potential β-cell imaging agent
B Wängler,Carmen Beck,Chyng Yann Shiue,Stephan Schneider,Christina Schwanstecher,Mathias Schwanstecher,Peter J. Feilen,Abass Alavi,Frank Rösch,Ralf Schirrmacher +9 more
TL;DR: The 11C-labeled sulfonylurea receptor 1 (SUR1) ligand (S)-2-([11C]methoxy)-4-[3-methyl-1-(2-piperidine-1-yl-phenyl)-butyl-carbamoyl]-benzoic acid was synthesized in an overall radiochemical yield of 35% after 55 min with a radiochemical purity higher than 99%.
36