Peter Höök
Columbia University
20 Papers
198 Citations
Peter Höök is an academic researcher from Columbia University. The author has contributed to research in topics: Myosin & Dynein. The author has an hindex of 15, co-authored 19 publications. Previous affiliations of Peter Höök include Karolinska Institutet & University of Notre Dame.
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Papers
Changes in myosin structure and function in response to glycation.
TL;DR: Glycation of skeletal muscle myosin has a significant effect on both the structural and functional properties of the protein, a finding that is important in understanding the mechanisms underlying the impairment in muscle function associated with aging and diabetes.
147
In vitro motility speed of slow myosin extracted from single soleus fibres from young and old rats
TL;DR: It is concluded that an age‐related alteration in myosin contributes to the slowing of the maximum shortening velocity (V0) observed in soleus muscle fibres expressing the β/slow MyHC isoform.
98
Actomyosin interactions in a novel single muscle fiber in vitro motility assay.
Peter Höök,Lars Larsson +1 more
TL;DR: The motility speed and maximum velocity of unloaded shortening in single fibers were well correlated, indicating that filament speed is a good molecular analogue to contractile speed at the fiber level, and offers a unique possibility to compare the regulatory and modulatory influence of myosin isoforms and thin filament proteins on shortening velocity, at the cellular and molecular level in the same muscle fiber.
61
Long range allosteric control of cytoplasmic dynein ATPase activity by the stalk and C-terminal domains.
TL;DR: A model for long range allosteric control of product release at AAA1 and AAA3 through the microtubule-binding stalk and the C-terminal domain, the latter of which may interact with AAA1 to close the motor domain ring in a cross-bridge cycle-dependent manner is proposed.
60
Molecular motors: A magnificent machine.
Richard B. Vallee,Peter Höök +1 more
TL;DR: In this article, the motor protein dynein was found to have a degree of gymnastic ability that is rarely seen. And the protein exhibited a high degree of flexibility in the movements of various structural regions.
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