Peter Herter

TL;DR: It is demonstrated that the nuclear APC protein level is high in cells in the basal crypt region of the normal colorectal epithelium, and staining resembles the staining pattern of a nuclear proliferation marker.

TL;DR: Besides its role in cell adhesion, β-catenin exerts a function as an oncoprotein in sarcomas with intracytoplasmic and nuclear localization with binding to nuclear DNA and a previously discussed stimulation of cell proliferation caused by an increased β- catenin level can be postulated for high-grade soft tissue sarcoma in correlation with the rate of proliferation.

TL;DR: The results point to an extensive redistribution of β-catenin, which starts early in colorectal tumorigenesis, and could serve as a criterion for estimating the malignant potential in the clinico-pathological evaluation of colon tumors during their early progression.

TL;DR: Results suggest that, pharmacologically, d-glucose uptake can be regulated by a shift of SGLT1 between the plasma membrane and the endosomal pool; however, regulation by the physiological substrate d- glucose can be explained only by an alternative mechanism.