Peter Henklein
Humboldt University of Berlin
180 Papers
1.9K Citations
Peter Henklein is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Receptor & Peptide sequence. The author has an hindex of 45, co-authored 179 publications. Previous affiliations of Peter Henklein include Gladstone Institutes & Utrecht University.
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Papers
A novel influenza A virus mitochondrial protein that induces cell death
Weisan Chen,Paul A. Calvo,Daniela Malide,James P. Gibbs,Ulrich Schubert,Igor Bacik,Sameh Basta,Robert E. O'Neill,Jeanne Schickli,Peter Palese,Peter Henklein,Jack R. Bennink,Jonathan W. Yewdell +12 more
TL;DR: It is proposed that PB1-F2 functions to kill host immune cells responding to influenza virus infection, and influenza viruses with targeted mutations that interfere with PB1/F2 expression induce less extensive apoptosis in human monocytic cells than those with intact PB1 -F2.
1.1K
COP9 signalosome‐specific phosphorylation targets p53 to degradation by the ubiquitin system
Dawadschargal Bech-Otschir,Regine Kraft,Xiaohua Huang,Peter Henklein,Barbara Kapelari,Christian Pollmann,Wolfgang Dubiel +6 more
TL;DR: It is shown that COP9 signalosome (CSN)‐specific phosphorylation targets human p53 to ubiquitin–26S proteasome‐dependent degradation, and a phosphorylated peptide, Δp53(145–164), specifically inhibits CSN‐mediatedosphorylation and p53 degradation.
SIRT1 regulates HIV transcription via Tat deacetylation.
Sara Pagans,Angelika Pedal,Brian J. North,Katrin Kaehlcke,Brett Marshall,Alexander Dorr,Claudia Hetzer-Egger,Peter Henklein,Roy A. Frye,Michael W. McBurney,Henning Hruby,Manfred Jung,Eric Verdin,Melanie Ott +13 more
TL;DR: It is reported here that Tat is deacetylated by human sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent class III protein de acetylase in vitro and in vivo, which supports a model in which cycles of Tat acetylation and deacetyation regulate HIV transcription.
An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope.
Ulrike Seifert,Concepción Marañón,Ayelet Shmueli,Jean-François Desoutter,Lisa M. Wesoloski,Katharina Janek,Peter Henklein,Susanne Diescher,Muriel Andrieu,Toni Weinschenk,Hansjoerg Schild,Diego Laderach,Anne Galy,Gaby Haas,Peter-M. Kloetzel,Yuval Reiss,Anne Hosmalin +16 more
TL;DR: It is proposed that Tripeptidyl peptidase II can act in combination with or independent of the proteasome system and can generate epitopes that evade generation by the protease-system.
248
The uronium/guanidinium Peptide coupling reagents: finally the true uronium salts.
Louis A. Carpino,Hideko Imazumi,Ayman El-Faham,Fernando J. Ferrer,Chongwu Zhang,Yunsub Lee,Bruce M. Foxman,Peter Henklein,Christiane Hanay,Clemens Mügge,Holger Wenschuh,Jana Klose,Michael Beyermann,Michael Bienert +13 more
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