Peter G. Klimko
Novartis
59 Papers
574 Citations
Peter G. Klimko is an academic researcher from Novartis. The author has contributed to research in topics: Ocular hypertension & Glaucoma. The author has an hindex of 17, co-authored 59 publications. Previous affiliations of Peter G. Klimko include Bosch & Alcon.
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Papers
•Journal Article
AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor
TL;DR: The results suggest that AL-8810 is a unique, selective antagonist at the FP receptor, a heretofore unavailable pharmacological tool that should be valuable for studying FP receptor-mediated functional responses in complex biological systems.
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Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist.
Mark R. Hellberg,Marsha A. McLaughlin,N.A. Sharif,Louis Desantis,Thomas R. Dean,Evan P. Kyba,John E Bishop,Peter G. Klimko,Paul W Zinke,Robert D. Selliah,George Barnes,Joseph M. deFaller,Angela C. Kothe,Theresa A. Landry,E. Kenneth Sullivan,Russell M. Andrew,Alberta A Davis,Lewis H. Silver,Michael V.W. Bergamini,Stella M. Robertson,Alan L. Weiner,Verney L. Sallee +21 more
TL;DR: Clinical studies show that travoprost 0.004% (isopropyl ester) provided intraocular pressure control superior to timolol 0.5% when used as monotherapy in patients with open-angle glaucoma or ocular hypertension, and AL-6598 0.01% provided a sustained intraocular Pressure reduction with q.i.d. application.
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The Hydrolysis of the Prostaglandin Analog Prodrug Bimatoprost to 17-Phenyl-trinor PGF2α by Human and Rabbit Ocular Tissue
TL;DR: Separate in vitro studies clearly show that both bimatoprost and 17-phenyl-trinor PGF(2alpha) have affinity for and are agonists at the human FP receptor, and strongly suggests that the ocular hypotensive effect of bim atoprost can be attributed to its activity as a prostaglandin receptor agonist either directly or through its role as a prodrug.
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Patent
substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives
Robert D. Selliah,Mark R. Hellberg,Peter G. Klimko,Verney L. Sallee,Paul W Zinke +4 more
- 12 Nov 1996
TL;DR: Substituted tetrahydrofuran analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed in this article.
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Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.
Zixia Feng,Suchismita Mohapatra,Peter G. Klimko,Mark R. Hellberg,Jesse A. May,Curtis R. Kelly,Gary W. Williams,Marsha A. McLaughlin,Najam A. Sharif +8 more
TL;DR: A series of 8-substituted benzodifuran analogs was prepared and evaluated for 5-HT(2A) receptor binding and activation and several compounds containing ether and ester functionality were found to be potent agonists.
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