Peter E. Maligres
Merck & Co.
83 Papers
432 Citations
Peter E. Maligres is an academic researcher from Merck & Co.. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 23, co-authored 80 publications.
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Papers
Silyl Phosphorus and Nitrogen Donor Chelates for Homogeneous Ortho Borylation Catalysis
Behnaz Ghaffari,Sean M. Preshlock,Donald L. Plattner,Richard J. Staples,Peter E. Maligres,Shane W. Krska,Robert E. Maleczka,Milton R. Smith +7 more
TL;DR: Ir catalysts supported by bidentate silyl ligands that contain P- or N-donors are shown to effect ortho borylations for a range of substituted aromatics.
A highly catalytic robust palladium catalyzed cyanation of aryl bromides
TL;DR: A dependable high yielding palladium catalyzed aryl bromide cyanation procedure has been developed in this paper, which features extremely low levels of palladium and DPPF ligand.
148
Engineered ribosyl-1-kinase enables concise synthesis of molnupiravir, an antiviral for covid-19
John A. McIntosh,Tamas Benkovics,Steven M. Silverman,Mark A. Huffman,Jongrock Kong,Peter E. Maligres,Tetsuji Itoh,Hao Yang,Deeptak Verma,Weilan Pan,Hsing-I Ho,Jonathan Vroom,Anders M. Knight,Jessica A. Hurtak,Artis Klapars,Anna Fryszkowska,William J. Morris,Neil A. Strotman,Grant S. Murphy,Kevin M. Maloney,Patrick S. Fier +20 more
TL;DR: In this paper, a short and sustainable synthesis of molnupiravir (MK-4482) from simple raw materials that would minimize the time needed to manufacture and supply moln upiravirus was proposed, enabled by the invention of a novel biocatalytic cascade featuring an engineered ribosyl-1kinase and uridine phosphorylase.
138
A multifunctional catalyst that stereoselectively assembles prodrugs
Daniel A. DiRocco,Yining Ji,Edward C. Sherer,Artis Klapars,Mikhail Reibarkh,James F. Dropinski,Rose Mathew,Peter E. Maligres,Alan M. Hyde,John Limanto,Andrew Brunskill,Rebecca T. Ruck,Louis-Charles Campeau,Ian W. Davies +13 more
TL;DR: A metal-free, small-molecule catalyst that attains high selectivity for nucleoside phosphoramidation by activating both reaction partners and a rational design of a multifunctional catalyst that enables stereoselectivity as high as 99:1 is described.
137
C ? O Cross-Coupling of Activated Aryl and Heteroaryl Halides with Aliphatic Alcohols
TL;DR: A robust and general catalyst system facilitates the alkoxylation of activated heteroaryl halides with primary, secondary, and select tertiary alcohols without the need for an excess of either coupling partner.
78