Peter Driemert
9 Papers
Peter Driemert is an academic researcher. The author has contributed to research in topics: Metabolome & Medicine. The author has an hindex of 1, co-authored 5 publications.
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Papers
Investigating the gut microbiome and metabolome following treatment with artificial sweeteners acesulfame potassium and saccharin in young adult Wistar rats.
Aishwarya Murali,Varun Giri,H. Cameron,Saskia Sperber,Franziska M. Zickgraf,Volker Haake,Peter Driemert,T. Walk,Hennicke Kamp,Ivonne M.C.M. Rietjens,Bennard van Ravenzwaay +10 more
TL;DR: In this paper , Wistar rats from both sexes were treated for 28 days with acesulfame potassium (40 and 120 mg/kg body weight) and saccharin (20 and 100 mg/ kg body weight). Targeted MS-based metabolome profiling and fecal 16S gene sequencing were conducted.
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A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil.
Varun Giri,Franziska M. Zickgraf,Volker Haake,Stefan Henkes,Peter Driemert,Wibke Busch,Stefan Scholz,Burkhard Flick,Marta Barenys,Barbara Birk,Hennicke Kamp,Robert Landsiedel,Dorothee Funk-Weyer +12 more
TL;DR: In this article , the effects of 6-propyl-2-thiouracil (PTU) exposure on zebrafish embryos were investigated through LC-MS/MS and GC-MS metabolomics, and changes to the endogenous metabolites can indicate pathways associated with developmental toxicity.
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Connecting Gut Microbial Diversity with Plasma Metabolome and Fecal Bile Acid Changes Induced by the Antibiotics Tobramycin and Colistin Sulfate.
Aishwarya Murali,Varun Giri,Franziska M. Zickgraf,Philipp Ternes,H. Cameron,Saskia Sperber,Volker Haake,Peter Driemert,Hennicke Kamp,Dorothee Funk-Weyer,Shana J. Sturla,Ivonne M.C.M. Rietjens,Bennard van Ravenzwaay +12 more
TL;DR: In this paper , a 28-day oral treatment with the antibiotics tobramycin or colistin sulfate was found to cause a strong reduction in the diversity and relative abundance of the microbiome of Wistar rats.
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A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity
S. Ramírez-Hincapié,Barbara Birk,Philipp Ternes,Varun Giri,Volker Haake,Michael Manfred Herold,Franziska M. Zickgraf,A. Verlohner,Hans Albrecht Huener,Hennicke Kamp,Peter Driemert,Robert Landsiedel,Elke Richling,Dorothee Funk-Weyer,Bennard van Ravenzwaay +14 more
TL;DR: In this paper , a 96-well plate LC-MS/MS-based targeted metabolomics screening platform for the classification of liver toxicity modes of action (MoAs) in HepG2 cells is presented.
Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish.
Pia Wilhelmi,Volker Haake,Franziska M. Zickgraf,Varun Giri,Philipp Ternes,Peter Driemert,Julia Nöth,Stefan Scholz,Marta Barenys,B. Flick,Barbara Birk,Hennicke Kamp,R. Landsiedel,Dorothee Funk-Weyer +13 more
TL;DR: The identification of molecular perturbations representative of antiangiogenesis in zebrafish embryo (ZFE) may guide the assessment of developmental toxicity from an endpoint- to a mechanism-based approach, thereby improving the extrapolation of findings to humans.