Peter De Sutter
Ghent University
6 Papers
Peter De Sutter is an academic researcher from Ghent University. The author has contributed to research in topics: Cystic fibrosis & Medicine. The author has an hindex of 1, co-authored 1 publications.
Chat about Author
Papers
Pharmacokinetics of fluoroquinolones in critical care patients: A bio-analytical HPLC method for the simultaneous quantification of ofloxacin, ciprofloxacin and moxifloxacin in human plasma
Julie De Smet,Koen Boussery,Kirsten Colpaert,Peter De Sutter,Peter De Paepe,Johan Decruyenaere,Jan Van Bocxlaer +6 more
TL;DR: A high-performance liquid chromatographic method with fluorescence detection was developed and validated and applied to the analysis of samples which have been obtained from patients, participating in a pharmacokinetic study on moxifloxacin.
74
High throughput determination of the biofilm prevention concentration for Pseudomonas aeruginosa biofilms using a synthetic cystic fibrosis sputum medium
Amber De Bleeckere,Sara Van den Bossche,Peter De Sutter,Tine Beirens,Aurélie Crabbé,Tom Coenye +5 more
TL;DR: In this article , a high throughput method was developed to determine the antimicrobial concentration required to prevent P. aeruginosa biofilm formation, using a synthetic cystic fibrosis sputum medium (SCFM2).
7
Altered intravenous drug disposition in people living with cystic fibrosis: A meta‐analysis integrating top‐down and bottom‐up data
Peter De Sutter,Maxime Van Haeverbeke,Eva Van Braeckel,Stephanie Van Biervliet,Jan Van Bocxlaer,An Vermeulen,Elke Gasthuys +6 more
TL;DR: Lower total plasma concentrations of drugs can be expected in people living with CF, especially when pulmonary exacerbations are present, and the clinical relevance of adapting existing dosage regimens should be evaluated on a case‐by‐case basis.
6
Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling
Peter De Sutter,Phebe Rossignol,Lien Breëns,Elke Gasthuys,An Vermeulen +4 more
TL;DR: Comparisons of two physiologically based pharmacokinetic Vss prediction methods in neonates with isometrical scaling highlight both the limitations and the applicability of PBPK methods for the prediction of Vss in the absence of clinical data.
4
Comparison of monoclonal antibody disposition predictions using different physiologically based pharmacokinetic modelling platforms.
Peter De Sutter,Elke Gasthuys,An Vermeulen +2 more
TL;DR: Overall, these simulations show that the different PBPK platforms generally predict similar mAb serum concentrations, but variable tissue concentrations, and caution is warranted when P BPK models are used to simulate effect site tissue concentrations of mAbs without data to verify the predictions.
1