Peter D. Mabbitt
Australian National University
18 Papers
30 Citations
Peter D. Mabbitt is an academic researcher from Australian National University. The author has contributed to research in topics: Biology & Ubiquitin ligase. The author has an hindex of 10, co-authored 13 publications.
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Papers
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.
Nathan W. Zammit,Nathan W. Zammit,Owen M. Siggs,Owen M. Siggs,Paul Gray,Keisuke Horikawa,David B. Langley,David B. Langley,Stacey N. Walters,Stacey N. Walters,Stephen R. Daley,Stephen R. Daley,Claudia Loetsch,Joanna Warren,Joanna Warren,Jin Yan Yap,Daniele Cultrone,Daniele Cultrone,Amanda J. Russell,Elisabeth K. Malle,Jeanette E. Villanueva,Mark J. Cowley,Mark J. Cowley,Velimir Gayevskiy,Marcel E. Dinger,Marcel E. Dinger,Robert Brink,Robert Brink,David Zahra,David Zahra,Geeta Chaudhri,Gunasegaran Karupiah,Gunasegaran Karupiah,Belinda Whittle,Carla M. Roots,Edward M. Bertram,Michiko Yamada,Yogesh Jeelall,Anselm Enders,Benjamin E. Clifton,Peter D. Mabbitt,Colin J. Jackson,Susan R. Watson,Craig N. Jenne,Craig N. Jenne,Lewis L. Lanier,Tim Wiltshire,Matthew H. Spitzer,Matthew H. Spitzer,Garry P. Nolan,Frank Schmitz,Frank Schmitz,Alan Aderem,Benjamin T. Porebski,Ashley M. Buckle,Derek W. Abbott,John B. Ziegler,Maria E. Craig,Maria E. Craig,Paul Z. Benitez-Aguirre,Juliana Teo,Stuart G. Tangye,Stuart G. Tangye,Cecile King,Cecile King,Melanie Wong,Murray P. Cox,Wilson Phung,Jia Tang,Wendy Sandoval,Ingrid E. Wertz,Daniel Christ,Daniel Christ,Christopher C. Goodnow,Christopher C. Goodnow,Shane T. Grey,Shane T. Grey +76 more
TL;DR: Genetic analyses of anatomically modern humans, extinct Denisovan hominins and mice revealed a TNFAIP3 allelic series with alterations in the encoded immune response inhibitor A20, which lower A20 activity and increase autoinflammatory responses.
64
Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability.
Nicholas J. Fraser,Jian-Wei Liu,Peter D. Mabbitt,Galen J. Correy,Chris W. Coppin,Mathilde Lethier,Matthew A. Perugini,James M. Murphy,John G. Oakeshott,Martin Weik,Colin J. Jackson +10 more
TL;DR: Analysis of monomeric and dimeric LcαE7-4a crystal structures revealed that only one of the oligomerization-inducing mutations was located at a potential protein-protein interface, providing support for the hypothesis that oligomerized is a viable evolutionary strategy for protein stabilization.
51
The Structure and Stability of the Disulfide-Linked γS-Crystallin Dimer Provide Insight into Oxidation Products Associated with Lens Cataract Formation.
David C. Thorn,Aidan B. Grosas,Peter D. Mabbitt,Nicholas J. Ray,Colin J. Jackson,John A. Carver +5 more
TL;DR: The structure of a disulfide-linked dimer of human γS-crystallin that was obtained via oxidation of C24 is described and it is implied that early-onset and age-related forms of the disease share comparable development pathways.
43
Overcoming insecticide resistance through computational inhibitor design
Galen J. Correy,Daniel Zaidman,Alon Harmelin,Silvia Carvalho,Peter D. Mabbitt,Viviane Calaora,Peter J. James,Andrew C. Kotze,Colin J. Jackson,Nir London +9 more
TL;DR: Covalent virtual screening is used to produce nano-/picomolar boronic acid inhibitors of the carboxylesterase αE7 from the agricultural pest Lucilia cuprina as well as a common Gly137AspαE7 mutant that confers OP resistance.
41
Conformational Disorganization within the Active Site of a Recently Evolved Organophosphate Hydrolase Limits Its Catalytic Efficiency
Peter D. Mabbitt,Galen J. Correy,Tamara Meirelles,Nicholas J. Fraser,Michelle L. Coote,Colin J. Jackson +5 more
TL;DR: An X-ray crystal structure of LcαE7:Gly137Asp is presented that, along with kinetic data, suggests that Asp137 acts as a general base in the new catalytic mechanism, and the conformation observed in the crystal structure obstructs the active site and is not catalytically productive.