Peter Cheung
Ontario Institute for Cancer Research
6 Papers
28 Citations
Peter Cheung is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: Histone & Histone code. The author has an hindex of 5, co-authored 6 publications.
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Papers
Epigenetic Regulation by Histone Methylation and Histone Variants
TL;DR: An overview of recent findings that shape the current paradigms regarding the roles of histone methylation and histone variants in heterochromatin assembly and the maintenance of the boundaries between heterochROMatin and euchromatin is provided.
Generation and characterization of antibodies directed against di-modified histones, and comments on antibody and epitope recognition.
TL;DR: The approach and methods used in generating and purifying the polyclonal Phos Ser10/Ac Lys14 di-modified H3 antibody (hereafter Phos/Ac H3 Ab) from rabbit serum are described, showing that H3 phosphorylation in mammalian cells is induced upon epidermal growth factor stimulation and correlates with transcription activation of the immediate early genes.
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Elucidating combinatorial histone modifications and crosstalks by coupling histone-modifying enzyme with biotin ligase activity
TL;DR: A novel nucleosome purification method based on physical coupling of the enzymatic activity of a histone-modifying enzyme with in vivo biotinylation by the biotin ligase BirA is used, and using streptavidin to purify the co-modified nucleosomes is used to study MSK1-mediated H3 phosphorylation.
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Chromatin Immunoprecipitation Assay for Mammalian Tissues
TL;DR: ChIP allows researchers to determine the status of both histone modifications and the nuclear effector proteins located at gene of interest and, if applied globally, can also reveal how chromatin structures are dynamically changed when cells respond to certain stimuli.
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Histone Phosphorylation: Chromatin Modifications that Link Cell Signaling Pathways to Nuclear Function Regulation
Priscilla Nga Ieng Lau,Peter Cheung +1 more
- 01 Jan 2010
TL;DR: This chapter highlights the diverse signaling pathways that converge onto chromatin, the kinases that phosphorylate specific residues on the different histones, and the various cellular processes that are regulated by this modification.
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