Peter Cernacek
Montreal Heart Institute
32 Papers
833 Citations
Peter Cernacek is an academic researcher from Montreal Heart Institute. The author has contributed to research in topics: Endothelin 1 & Pulmonary hypertension. The author has an hindex of 20, co-authored 32 publications. Previous affiliations of Peter Cernacek include St. Michael's Hospital.
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Papers
Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?
TL;DR: In patients with primary pulmonary hypertension, the high levels in arterial compared with venous plasma suggest pulmonary production of endothelin-1, which may contribute to elevated pulmonary vascular resistance.
1K
Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes. The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) trial.
TL;DR: Cholesterol reduction with pravastatin initiated early after acute coronary syndromes rapidly improves endothelial function after 6 weeks of therapy, and markers of platelet activation, coagulation factors, and plasma endothelin levels were not affected by pravastsatin.
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Increased plasma endothelin-1 in the early hours of acute myocardial infarction.
TL;DR: Plasma levels of endothelin-1 rose sharply after myocardial infarction, and left ventricular ejection fraction did not correlate with the increase in endothelins-1 in group I patients, whereas there was a significant inverse relation between ventricular function and plasma endothelimus in group II.
308
Endothelin A Receptor Blockade Causes Adverse Left Ventricular Remodeling but Improves Pulmonary Artery Pressure After Infarction in the Rat
Quang Trinh Nguyen,Peter Cernacek,Angelino Calderoni,Duncan J. Stewart,Pierre Picard,Pierre Sirois,Michel White,Jean L. Rouleau +7 more
TL;DR: The early use of the ETA receptor antagonists LU 127043 or its active enantiomer LU 135252 after infarction in the rat leads to impaired scar healing and LV dilatation and dysfunction, accompanied by a decrease in RV systolic and right atrial pressures and a decreases in pulmonary but not cardiac ET-1 levels.
118
Effectiveness of a Nonselective ETA/B and a Selective ETA Antagonist in Rats With Monocrotaline-Induced Pulmonary Hypertension
TL;DR: In this article, the ETA/B receptor and selective ETA receptor antagonists can reduce pulmonary hypertension and right ventricular hypertrophy (RVH) in various animal models.
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