Background:  The native porcine zona pellucida (pZP) vaccine has been successfully used for immunocontraception of wild horses, white-tailed deer and approximately 90 zoo species for more than 25 years. Objectives:  To provide proof of concept and test contraceptive efficacy of pZP in African elephants. Once completed, test the population and behavioural effects on cows in the Greater Makalali Private Game Reserve (GMPGR). Following the GMPGR, test efficacy, population effects, safety and reversibility in 25 reserves with populations ranging from 9 to 700 elephants. Method:  Histological sections were reacted with anti-pZP antibodies to provide proof of concept. From 1996 to 2000, 21 and 10 cows were treated with pZP vaccine in the Kruger National Park (KNP) and monitored for pregnancy. Population effects of pZP with Freund’s adjuvants (three vaccinations in Year 1 with one annual booster) were studied on 18 cows in the GMPGR. Another six game reserves with a total of 90 cows were added to the project. The project was then expanded to include another 18 reserves. Results:  Binding of anti-pZP antibodies to elephant zona proteins was demonstrated  in vitro . The KNP provided efficacy results of 56% and 80%, respectively. The contraceptive efficacy in the GMPGR and additional six reserves was 100% following calving of pregnant cows. Safety and lack of impact on social behaviour were demonstrated. In larger populations, efficacy was > 95%. Conclusion:  Contraceptive efficacy and safety of pZP vaccine could be demonstrated in small to large populations. The methodology is now being implemented in approximately 800 cows on 26 reserves across South Arica.

/pdf/porcine-zona-pellucida-vaccine-immunocontraception-of-2olrljiu2b.pdf

Porcine zona pellucida vaccine immunocontraception of African elephant (Loxodonta africana) cows : a review of 22 years of research

Context Managed wild lions (Panthera leo) are lions found in smaller (<1000 km2), fenced protected areas that hold a substantial portion of South Africa’s wild lion population. Because the natural population control mechanisms are compromised within these properties, managers must actively control population growth rates. Fecundity control is used by wildlife managers, but long-term, empirical data on the impact and consequences of such interventions in lions are lacking. Aims The aim of the present study was to assess the effectiveness of two methods of contraception (deslorelin implant and unilateral hysterectomy) in reducing cub recruitment of managed wild lions. Methods Survey data spanning 14 years from 94 managed wild lions on 19 protected areas were used to evaluate the effectiveness of deslorelin implant treatments and unilateral hysterectomies on population growth rates through mimicking open system cub recruitment. Key results Deslorelin implants were effective at increasing the age of first reproduction and lengthening inter-birth intervals. There was also an unexpected decrease in litter size. Behavioural side-effects were recorded in 40% of individuals: 19% pride fragmentation; 13% lack of receptiveness towards males; 8% other. The more successive deslorelin implants a lioness had, the more likely it was that weight gain was reported. Unilateral hysterectomy resulted in a decrease in litter size post-surgery, but this was not statistically significant. No behavioural or physiological side-effects were noted after unilateral hysterectomy. Conclusions Deslorelin treatment was more effective in reducing the reproductive output of managed wild lionesses than unilateral hysterectomy surgery. While more side-effects were associated with deslorelin implants than unilateral hysterectomies, a single deslorelin treatment is currently a good option for fecundity reduction. More research is required on unilateral hysterectomy surgery. Implications Neither deslorelin implants nor unilateral hysterectomies offer a ‘silver bullet’ solution for reducing rapid population growth in managed wild lions. Reproductive control should be integrated with other best-practice approaches.

The use of contraceptive techniques in managed wild African lion (Panthera leo) populations to mimic open system cub recruitment

Effects of a Recombinant Gonadotropin-Releasing Hormone Vaccine on Reproductive Function in Adult Male ICR Mice.

No evidence for detrimental effect of chemical castration on working ability in Swiss military dogs

History of non-surgical contraceptions in dogs and cats

Contents
Generally speaking, southern Africa's wildlife populations in small-to-medium-sized protected game reserves (10,000–65,000 ha) reproduce at rapid rates which often lead overpopulation of certain species. Most commonly these are large predators such as lions, African wild dogs and cheetahs, and elephants. Overpopulation of large predators leads to depletion of prey species, breakouts into neighbouring communities and increased risks for disease transmission. An overabundance of elephants leads to habitat destruction which is to the detriment of not only other herbivores but also certain bird species. By far, the most acceptable and effective method of population control is contraception. Another problem, particularly in South Africa, is the large numbers of large predators that are held in zoos, wildlife sanctuaries or captive breeding facilities. Once again, there is a need for contraception to control the rate of reproduction. In this review, we discuss the methods that have been most commonly used for some wildlife species in southern Africa. The methods include hormonal control and immunocontraception. We also address the problem of androgen-related aggressive behaviours in elephant bulls and giraffe males and present solutions that have been used to ameliorate such behaviours.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/rda.12783

Fertility suppression of some wildlife species in southern Africa-a review.

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Fertility suppression of some wildlife species in southern Africa-a review.