of filter design in embolic protection for carotid artery stenting [8]. There are reviews on structural cardiac interventions. Dr De Wolf presents complications associated with atrial septal defect closure [9] and Dr Block discusses the role of left atrial appendage closure [10]. The technology associated with left ventricular assist devices is rapidly evolving, and Drs Tuseth and Nordrehaug present the role of percutaneous left ventricular assist devices in preventing cerebral ischemia [11]. Dr Meuwissen et al. discuss the role of coronary flow reserve in decision ana lysis of intermediate coronary lesions [12]. Drs Bolia and Adair present their techniques on treating very complex i nfrapopliteal lesions [13]. We are very excited to introduce this issue on cardiovascular interventions to you.

/pdf/expanding-the-horizons-in-cardiovascular-interventions-4hnid9u3wf.pdf

Expanding the horizons in cardiovascular interventions

For patients with atrial fibrillation, successful warfarin therapy is difficult in clinical practice. Thus, it seems logical to find alternative therapies to chronic anticoagulation. The major source of thromboembolism in such patients is the left atrial appendage, and occlusion of the appendage with transcatheter devices is feasible, reduces anticipated stroke rates and has been found to be noninferior to warfarin therapy in a large, randomized trial. Trials with new devices are planned. In light of the current data, how patients with atrial fibrillation who need warfarin, who are either at risk with anticoagulation or who desire not to undergo warfarin therapy should best be treated is not clear. Hopefully, with more experience and longer term outcomes of clinical trials, these issues will finally be laid to rest.

/pdf/is-there-a-role-for-transcatheter-left-atrial-appendage-38sgbloait.pdf

Is there a role for transcatheter left atrial appendage occlusion

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Is there a role for transcatheter left atrial appendage occlusion