Peter A. Campochiaro
Johns Hopkins University School of Medicine
523 Papers
6.7K Citations
Peter A. Campochiaro is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Retinal & Retina. The author has an hindex of 108, co-authored 506 publications. Previous affiliations of Peter A. Campochiaro include Novartis & Johns Hopkins University.
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Papers
Gene Transfer of An Engineered Zinc Finger Protein Enhances the Anti-angiogenic Defense System
Katsutoshi Yokoi,Huanda Steve Zhang,Shu Kachi,Kamaljit S. Balaggan,Qi Yu,Dmitry Guschin,Mike Kunis,Richard T. Surosky,Liza M Africa,James W B Bainbridge,Sharon Kaye Spratt,Philip D. Gregory,Robin R. Ali,Peter A. Campochiaro +13 more
TL;DR: The data suggest that ZFP TF-driven enhancement of the endogenous anti-angiogenic defense system may provide a new approach for prophylaxis and treatment of neovascular diseases of the eye.
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Photoreceptor-specific overexpression of platelet-derived growth factor induces proliferation of endothelial cells, pericytes, and glial cells and aberrant vascular development: an ultrastructural and immunocytochemical study
TL;DR: Platelet-derived growth factor (PDGF) is necessary for the normal development of the retinal vasculature and its overexpression is likely to contribute to proliferative retinal disorders, such as proliferative vitreoretinopathy.
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•Journal Article
Stimulation of cyclic adenosine monophosphate accumulation causes breakdown of the blood-retinal barrier
H A Sen,Peter A. Campochiaro +1 more
TL;DR: Pigmented rabbits were given an intravitreous injection of 0.1 ml of various concentrations of test drug, and vitreous fluorophotometry was done 6 and 24 hours after injection as mentioned in this paper.
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Anisotropic poly(lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization
Jayoung Kim,Raquel Lima e Silva,Ron B. Shmueli,Adam C. Mirando,Stephany Y. Tzeng,Niranjan B. Pandey,Elana Ben-Akiva,Aleksander S. Popel,Peter A. Campochiaro,Jordan J. Green +9 more
TL;DR: A safe, poly(lactic-co-glycolic acid) (PLGA)-based biodegradable polymeric microparticle (MP) delivery system was developed that encapsulates and protects a biomimetic peptide from degradation, allows sustained intraocular release through polymer hydrolysis, and demonstrates a prolonged anti-angiogenic effect in vivo.
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Human retinal pigment epithelial cells possess V1 vasopressin receptors.
TL;DR: A specific vasopressin receptor antagonist, SKF 101926, prevented the AVP-induced increase in calcium mobilization and inositol phosphate production in RPE, suggesting that RPE cells possess V1 AVP receptors coupled to calcium mobilize and inposol phosphate metabolism.
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