Peter A. Campochiaro
Johns Hopkins University School of Medicine
523 Papers
6.7K Citations
Peter A. Campochiaro is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Retinal & Retina. The author has an hindex of 108, co-authored 506 publications. Previous affiliations of Peter A. Campochiaro include Novartis & Johns Hopkins University.
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Papers
Effects of different types of oxidative stress in RPE cells.
TL;DR: This study suggests that multiple types of oxidant stress should be used to probe the vulnerabilities of the retina and RPE in vivo, and that ELISA for carbonyl content provides a valuable tool for quantitative assessment of oxidative damage for such studies.
Gene expression variation in the adult human retina
Itay Chowers,Dongmei Liu,Ronald H. Farkas,Tushara L. Gunatilaka,Abigail S. Hackam,Steven L. Bernstein,Peter A. Campochiaro,Giovanni Parmigiani,Donald J. Zack +8 more
TL;DR: The findings show that a significant fraction of gene expression variation in the normal human retina is attributable to identifiable biological factors, which raises the possibility that photoreceptor gene expression levels may contribute to phenotypic diversity across normal adult retinas.
Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling.
Adam C. Mirando,Raquel Lima e Silva,Zenny Chu,Peter A. Campochiaro,Niranjan B. Pandey,Aleksander S. Popel +5 more
TL;DR: The data suggest that AXT107 may provide multiple benefits in the treatment of retinal/choroidal and other vascular diseases by suppressing inflammation and promoting vascular stabilization.
•Journal Article
Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors.
TL;DR: The hypothesis that BDNF, CNTF, and FGF2 exert their effects on photoreceptors by acting indirectly through activation of Müller cells and perhaps other nonphotoreceptor cells is supported.
•Journal Article
Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth.
Elia J. Duh,Hoseong S. Yang,Izumi Suzuma,Masaru Miyagi,Elaine M. Youngman,Keisuke Mori,Miyuki Katai,Lin Yan,Kiyoshi Suzuma,K.A. West,Shekar Davarya,Patrick Y Tong,Peter L. Gehlbach,Joel Pearlman,John W. Crabb,Lloyd Paul Aiello,Peter A. Campochiaro,Donald J. Zack +17 more
TL;DR: These data indicate that elevated concentrations of PEDF inhibit VEGF-induced retinal endothelial cell growth and migration and retinal neovascularization and suggest that localized administration of P EDF may be an effective approach for the treatment of ischemia-induced Retinal Neovascular disorders.