Periasamy Selvaraj
Emory University
110 Papers
1.2K Citations
Periasamy Selvaraj is an academic researcher from Emory University. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 33, co-authored 96 publications. Previous affiliations of Periasamy Selvaraj include Harvard University & Emory University Hospital.
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Papers
Anchoring mechanisms for LFA-3 cell adhesion glycoprotein at membrane surface
TL;DR: It is reported here that an immunologically important adhesion glycoprotein, lymphocyte function-associated antigen 3 (LFA-3), can be anchored to the membrane by both types of mechanism, including a phosphatidyl-inositol-linked and a transmembrane anchored form of L FA-3.
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Mechanisms for regulating expression of membrane isoforms of Fc gamma RIII (CD16).
Margaret L. Hibbs,Periasamy Selvaraj,Olli Carpén,Timothy A. Springer,Helmut Küster,M H Jouvin,Jean-Pierre Kinet +6 more
TL;DR: Mutagenesis shows that anchoring is regulated by a serine residue near the PIG anchor attachment site in the extracellular domain of granulocyte and natural killer cell Fc receptors for immunoglobulin G (CD16).
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Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor.
TL;DR: It is confirmed that LFA-3 is a cell adhesion molecule that mediates adhesion by interacting with CD2 antigen and is attached to the cell membrane by a phosphatidylinositol glycolipid moiety.
Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3).
Marian L. Plunkett,Martin E. Sanders,Periasamy Selvaraj,Michael L. Dustin,Timothy A. Springer +4 more
TL;DR: It is found that LFA-3 is expressed on human E, and that CD2 is a receptor for L FA-3 that mediates T cell adhesion to human E and is inhibited by pretreatment with purified CD2.
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Ligand binding and phagocytosis by CD16 (Fc gamma receptor III) isoforms. Phagocytic signaling by associated zeta and gamma subunits in Chinese hamster ovary cells.
TL;DR: The results demonstrate that glycosylphosphatidylinositol-anchored CD16B alleles differ from CD16A in their ability to mediate phagocytosis.
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