https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.24199

Management of hepatocellular carcinoma: An update

There is no consensus definition of acute renal failure (ARF) in critically ill patients. More than 30 different definitions have been used in the literature, creating much confusion and making comparisons difficult. Similarly, strong debate exists on the validity and clinical relevance of animal models of ARF; on choices of fluid management and of end-points for trials of new interventions in this field; and on how information technology can be used to assist this process. Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies. We undertook a systematic review of the literature using Medline and PubMed searches. We determined a list of key questions and convened a 2-day consensus conference to develop summary statements via a series of alternating breakout and plenary sessions. In these sessions, we identified supporting evidence and generated recommendations and/or directions for future research. We found sufficient consensus on 47 questions to allow the development of recommendations. Importantly, we were able to develop a consensus definition for ARF. In some cases it was also possible to issue useful consensus recommendations for future investigations. We present a summary of the findings. (Full versions of the six workgroups' findings are available on the internet at http://www.ADQI.net
 ) Despite limited data, broad areas of consensus exist for the physiological and clinical principles needed to guide the development of consensus recommendations for defining ARF, selection of animal models, methods of monitoring fluid therapy, choice of physiological and clinical end-points for trials, and the possible role of information technology.

/pdf/acute-renal-failure-definition-outcome-measures-animal-3m4l0j5jsf.pdf

Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.

Background: Understanding of the gut-liver axis is important for the up-to-date management of liver cirrhosis, and changes of intestinal functions form the core o

/pdf/changes-of-intestinal-functions-in-liver-cirrhosis-3jpifzc6ch.pdf

Changes of Intestinal Functions in Liver Cirrhosis

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.29367

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.20933

Management of hepatocellular carcinoma.

1. Sol a E, Sol e C, Gin es P. Management of uninfected and infected ascites in cirrhosis. Liver Int 2016; 36(Suppl. 1): 109–15. 2. Piano S, Fasolato S, Salinas F, et al. The empirical antibiotic treatment of nosocomial spontaneous bacterial peritonitis: results of a randomized, controlled clinical trial. Hepatology 2015; 63: 1299–309. 3. Friedrich K, N€ ussle S, Rehlen T, et al. Microbiology and resistence in first episodes of spontaneous bacterial peritonitis: implications for management and prognosis. J Gastroenterol Hepatol 2016; 31: 1191–5 4. Retamar P, L opezCerero L, Muniain MA, Pascual A, Rodr ıguez-Ba~ no J; ESBL-REIPI/GEIH Group. Impact of the MIC of piperacillin-tazobactam on the outcome of patients with bacteremia due to extended-spectrum-ßlactamase-producing Escherichia coli. Antimicrob Agents Chemother 2013; 57: 3402–4. 5. Stamatiadis D, Papaioannou MG, Giamarellos-Bourboulis EJ, et al. Pharmacokinetics of teicoplanin in patients undergoing continuous ambulatory peritoneal dialysis. Perit Dial Int 2003; 23: 127–31.

Response to nosocomial spontaneous bacterial peritonitis: discussing a specific infection treatment algorithm

Urinary proteomics identifies oxidative stress and inflammation pathways as key factors differentiating acute-kidney injury-hepatorenal syndrome from acute tubular necrosis in patients with cirrhosis

Ascites and hepatorenal syndrome

Beneficial effects of a screening programme for alcohol-related liver fibrosis with transient elastography in people with alcohol use disorder promoting alcohol abstinence

EASL International Recognition Award Recipient 2022: Prof. Patrick S. Kamath.

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