Per Hoffman
University of Bonn
7 Papers
16 Citations
Per Hoffman is an academic researcher from University of Bonn. The author has contributed to research in topics: Genome-wide association study & Aggressive periodontitis. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Per Hoffman include University of Basel.
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Papers
GWAS-based pathway analysis differentiates between fluid and crystallized intelligence
Andrea Christoforou,Andrea Christoforou,Thomas Espeseth,Thomas Espeseth,Gary Davies,Gary Davies,Carla P. D. Fernandes,Carla P. D. Fernandes,Sudheer Giddaluru,Sudheer Giddaluru,Manuel Mattheisen,Manuel Mattheisen,Albert Tenesa,Albert Tenesa,Sarah E. Harris,Sarah E. Harris,D. C. Liewald,Antony Payton,William Ollier,Michael A. Horan,Neil Pendleton,Paul Haggarty,Srdjan Djurovic,Stefan Herms,Stefan Herms,Per Hoffman,Sven Cichon,John M. Starr,Astri J. Lundervold,Astri J. Lundervold,Ivar Reinvang,Vidar M. Steen,Vidar M. Steen,Ian J. Deary,S. Le Hellard,S. Le Hellard +35 more
TL;DR: The gF–gC distinction at the genetic level is supported and functional annotations and pathways worthy of further investigation are identified and identified.
Heterogeneous contribution of microdeletions in the development of common generalised and focal epilepsies
Eduardo Pérez-Palma,Eduardo Pérez-Palma,Ingo Helbig,Karl Martin Klein,Verneri Anttila,Verneri Anttila,Heiko Horn,Eva M. Reinthaler,Padhraig Gormley,Padhraig Gormley,Andrea Ganna,Andrea Byrnes,Katharina Pernhorst,Mohammad R. Toliat,Elmo Saarentaus,Elmo Saarentaus,Daniel P. Howrigan,Daniel P. Howrigan,Per Hoffman,Juan Francisco Miquel,Giancarlo V. De Ferrari,Peter Nürnberg,Holger Lerche,Fritz Zimprich,Bern A. Neubauer,Albert John Becker,Felix Rosenow,Emilio Perucca,Federico Zara,Yvonne G. Weber,Dennis Lal,Dennis Lal,Dennis Lal +32 more
TL;DR: A heterogeneous effect of recurrent and non-recurrent microdeletions as part of the genetic architecture of GGE and a minor contribution in the aetiology of RE and AFE are shown.
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Genome-wide interaction and pathway-based identification of key regulators in multiple myeloma
Subhayan Chattopadhyay,Subhayan Chattopadhyay,Hauke Thomsen,Pankaj Yadav,Miguel Inacio da Silva Filho,Niels Weinhold,Markus M. Nöthen,Per Hoffman,Per Hoffman,Uta Bertsch,Stefanie Huhn,Gareth J. Morgan,Hartmut Goldschmidt,Richard S. Houlston,Kari Hemminki,Kari Hemminki,Asta Försti,Asta Försti +17 more
- 04 Mar 2019
TL;DR: This article carried out genome-wide interaction analyses on two European cohorts accounting for 3,999 cases and 7,266 controls and characterized genetic susceptibility to multiple myeloma with subsequent meta-analysis that discovered 16 unique interacting loci.
Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling
Nick Dand,Sören Mucha,Lam C. Tsoi,Satveer K. Mahil,Philip E. Stuart,Andreas Arnold,Hansjörg Baurecht,A. David Burden,Kristina Callis Duffin,Vinod Chandran,Charles Curtis,Charles Curtis,Sayantan Das,David Ellinghaus,Eva Ellinghaus,Charlotta Enerbäck,Tõnu Esko,Dafna D. Gladman,Dafna D. Gladman,Christopher E.M. Griffiths,Johann E. Gudjonsson,Per Hoffman,Per Hoffman,Georg Homuth,Ulrike Hüffmeier,Gerald G. Krueger,Matthias Laudes,Sang Hyuck Lee,Sang Hyuck Lee,Wolfgang Lieb,Henry W. Lim,Sabine Löhr,Ulrich Mrowietz,Martina Müller-Nurayid,Markus M. Nöthen,Annette Peters,Proton Rahman,André Reis,Nick J. Reynolds,Elke Rodriguez,Carsten Oliver Schmidt,Sarah L. Spain,Konstantin Strauch,Trilokraj Tejasvi,John J. Voorhees,Richard B. Warren,Michael Weichenthal,Stephan Weidinger,Matthew Zawistowski,Rajan P. Nair,Francesca Capon,Catherine H. Smith,Richard C. Trembath,Gonçalo R. Abecasis,James T. Elder,Andre Franke,Michael A. Simpson,Jonathan Barker +57 more
TL;DR: Previous reports of protective low-frequency protein-altering variants within IFIH1 and TYK2 (encoding an innate antiviral receptor and Janus kinase) are validated, establishing a further series of protective rare variants.
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
Emma C. Johnson,Douglas W. Bjelland,Daniel P. Howrigan,Abdel Abdellaoui,Gerome Breen,Anders D. Børglum,Sven Cichon,Franziska Degenhardt,Andreas J. Forstner,Josef Frank,Giulio Genovese,Stefanie Heilmann-Heimbach,Stefan Herms,Per Hoffman,Wolfgang Maier,Manuel Mattheisen,Derek W. Morris,Bryan J. Mowry,Betram Müller-Mhysok,Benjamin M. Neale,Benjamin M. Neale,Igor Nenadic,Markus M. Nöthen,Colm O'Dushlaine,Marcella Rietschel,Douglas M. Ruderfer,Dan Rujescu,Thomas G. Schulze,Matthew A. Simonson,Eli A. Stahl,Eli A. Stahl,Jana Strohmaier,Stephanie H. Witt,Patrick F. Sullivan,Matthew C. Keller +34 more
TL;DR: Repl replication results from 22 independent schizophrenia case-control datasets from the Psychiatric Genomics Consortium are described, unable to replicate the significant association between ROH burden and schizophrenia in the independent PGC phase II data, although the effect was in the predicted direction.