Per-Anders Frändberg
Uppsala University
7 Papers
81 Citations
Per-Anders Frändberg is an academic researcher from Uppsala University. The author has contributed to research in topics: Ifenprodil & Angiotensin II. The author has an hindex of 5, co-authored 7 publications.
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Papers
AT2-selective angiotensin II analogues containing tyrosine-functionalized 5,5-bicyclic thiazabicycloalkane dipeptide mimetics.
Petra Johannesson,Máté Erdélyi,Gunnar Lindeberg,Per-Anders Frändberg,Fred Nyberg,and Anders Karlén,Anders Hallberg +6 more
TL;DR: Conformational analysis, using experimental constraints derived from NMR studies, indicated that the Tyr(4) and His(6) residues in one of the angiotensin II analogues were in close proximity to each other.
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Molecular Mechanisms for Nanomolar Concentrations of Neurosteroids at NR1/NR2B Receptors
TL;DR: Results substantiate previous evidence of the allosteric modulatory effect induced by PS and 3α5βS on NMDA receptors at nanomolar concentrations and are reflected in an altered glutamate stimulated [Ca2+]i, in response to ifenprodil.
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Effect of 3-5 monocyclizations of angiotensin II and 4-aminophe6-ang II on AT2 receptor affinity
Susanna Lindman,Gunnar Lindeberg,Per-Anders Frändberg,Fred Nyberg,Anders Karlén,Anders Hallberg +5 more
TL;DR: The fact that different structure-activity relationships are observed after imposing conformational restrictions on Ang II and 4-aminoPhe(6)-Ang II, respectively, suggests that the peptides, despite large similarities, might adopt quite different backbone conformations when binding to the AT(2) receptor.
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Low concentrations of neuroactive steroids alter kinetics of [3H]ifenprodil binding to the NMDA receptor in rat frontal cortex
TL;DR: The present study show that the allosteric modulators PS or 3α5βS change [3H]ifenprodil binding kinetics in a way indicating conformational alteration of its binding site on the NR2B subunit.
Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells
Tobias Johansson,Martin Elfverson,Carolina Birgner,Per-Anders Frändberg,Fred Nyberg,Pierre Le Grevès +5 more
TL;DR: The interaction with the NR2B-selective antagonist ifenprodil indicates that this NMDA receptor subunit may be involved in neurosteroid-induced NG108-15 cell detachment.
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