Pengfei Meng
Hirosaki University
12 Papers
10 Citations
Pengfei Meng is an academic researcher from Hirosaki University. The author has contributed to research in topics: MDA5 & Carnosic acid. The author has an hindex of 7, co-authored 8 publications.
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Papers
Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells.
Pengfei Meng,Hidemi Yoshida,Kunikazu Tanji,Tomoh Matsumiya,Fei Xing,Ryo Hayakari,Liang Wang,Kazushi Tsuruga,Hiroshi Tanaka,Junsei Mimura,Kunio Kosaka,Ken Itoh,Ippei Takahashi,Shogo Kawaguchi,Tadaatsu Imaizumi +14 more
TL;DR: Results suggest that CA suppressed the activation of Casp cascades by reducing the intracellular oligomerization of exogenous Aβ42/43 monomer and may have a potential in the prevention of Aβ-mediated diseases, particularly AD.
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Carnosic acid suppresses the production of amyloid-β 1–42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells
Pengfei Meng,Hidemi Yoshida,Tomoh Matsumiya,Tadaatsu Imaizumi,Kunikazu Tanji,Fei Xing,Ryo Hayakari,Junichi Dempoya,Tetsuya Tatsuta,Tomomi Aizawa-Yashiro,Junsei Mimura,Kunio Kosaka,Ken Itoh,Kei Satoh +13 more
TL;DR: It is suggested that CA reduces Aβ42 production by activating TACE without promoting BACE1 in human neuroblastoma cells and the use of CA may have a potential in the prevention of Aβ-mediated diseases, particularly AD.
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Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells
Hidemi Yoshida,Pengfei Meng,Tomoh Matsumiya,Kunikazu Tanji,Ryo Hayakari,Fei Xing,Liang Wang,Kazushi Tsuruga,Hiroshi Tanaka,Junsei Mimura,Kunio Kosaka,Ken Itoh,Ippei Takahashi,Tadaatsu Imaizumi +13 more
TL;DR: It is suggested that carnosic acid reduces Aβ production, at least partially, by activating TACE in human astroglial cells.
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Tumor necrosis factor-α synergistically enhances polyinosinic-polycytidylic acid-induced toll-like receptor 3 signaling in cultured normal human mesangial cells: possible involvement in the pathogenesis of lupus nephritis.
Tadaatsu Imaizumi,Tomomi Aizawa,Ryo Hayakari,Fei Xing,Pengfei Meng,Kazushi Tsuruga,Tomoh Matsumiya,Hidemi Yoshida,Liang Wang,Tetsuya Tatsuta,Hiroshi Tanaka +10 more
TL;DR: Synergistic effect of TNF-α and “pseudoviral” infection is possibly involved in the development of LN.
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TLR4 signaling induces retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 in mesangial cells.
Tadaatsu Imaizumi,Tomomi Aizawa-Yashiro,Shojiro Watanabe,Tomoh Matsumiya,Hidemi Yoshida,Tetsuya Tatsuta,Fei Xing,Pengfei Meng,Ryo Hayakari,Kazushi Tsuruga,Hiroshi Tanaka +10 more
TL;DR: RIG-I and MDA5 may be involved in inflammatory reactions by regulating CXCL10 expression in the downstream of TLR4 signaling in human mesangial cells.
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