Peng Wang

TL;DR: A complex approach including the prediction of the structure of metabolite, high-throughput in silico screening, and network reconstruction and analysis was developed to obtain a computational drug-target network for YZP and provide some evidence for exploring the classic TCM formulas for new clinical application.

Abstract: China is in fronting severe air pollution due to rapid industrialization and urbanization, which significantly threatens public health. Since 2013, the Chinese Government has implemented “Clean Air Action” with consecutive emission control policies to improve air quality. The “Clean Air Action” Phase I (2013-2017) and Phase II (2018-2020) mainly targeted alleviating the fine particulate matter (PM 2.5 ) and ozone (O 3 ) concentrations, respectively. However, it remains unclear how these policies have impacted air quality since most previous studies merely focus on Phase I. In addition, meteorology plays an important role in air pollution formation. It is urgent to conduct a compressive study to evaluate the response of air quality in China to changes in metrology and emissions. In this study, we applied the Community Multiscale Air Quality (CMAQ) model to investigate variations of air quality in China during “Clean Air Action” Phase I and Phase II (from 2013-2020). Results show that PM 2.5 is significantly reduced (up to 40%) across China from 2013 to 2020 except in summer when the rising PM 2.5 is predicted in Southern China due to the enhanced atmospheric oxidation capacity. On average, the O 3 concertation also decreases (-7%) from 2013-2020, but a 3% increase of O 3 is found in the Beijing-Tianjin-Hebei (BTH) region. Emission changes play a dominant role in the reduction of PM 2.5 (over 95%). For O 3 , the contributions from meteorology and emissions to O 3 reduction are 46% and 54%, respectively. The unfavorable meteorological conditions such as high-temperature even facilitate the co-occurrence of high PM 2.5 and O 3 . Our results suggest that a more effective emission abatement strategy

TL;DR: The results found that BX-YYR against insomnia might play a role in improving sleep by modulating the serotonergic pathway, and provided an objective basis for further experimental study and clinical application.

TL;DR: In this paper , a putative alginate lyase with two functional catalytic domains (CD1 and CD2) from the marine alginates-degrading strain Vibrio sp. C42 was characterized in Escherichia coli.