32 Papers
16 Citations
Peng Wang is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Beta cell & Cell growth. The author has an hindex of 13, co-authored 23 publications.
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Papers
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
Peng Wang,Juan-Carlos Alvarez-Perez,Dan P. Felsenfeld,Hongtao Liu,Sharmila Sivendran,Aaron Bender,Anil Kumar,Roberto Sanchez,Donald K. Scott,Adolfo Garcia-Ocaña,Andrew F. Stewart +10 more
TL;DR: Using three different mouse and human islet in vivo–based models, harmine is able to induce beta cell proliferation, increase islet mass and improve glycemic control, suggesting that harmine analogs may have unique therapeutic promise for human diabetes therapy.
Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells
Peng Wang,Esra Karakose,Hongtao Liu,Ethan A Swartz,Courtney Ackeifi,Viktor Zlatanic,Jessica Wilson,Bryan J. González,Aaron Bender,Karen K. Takane,Lillian Ye,George Harb,Felicia Pagliuca,Dirk Homann,Dieter Egli,Carmen Argmann,Donald K. Scott,Adolfo Garcia-Ocaña,Andrew F. Stewart +18 more
TL;DR: Combined pharmacologic inhibition of DYRK1A and transforming growth factor beta superfamily (TGFβSF)/SMAD signaling generates remarkable further synergistic increases in human beta cell proliferation, and increases in both mouse and human beta cells numbers.
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Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas
Huan Wang,Huan Wang,Aaron Bender,Peng Wang,Esra Karakose,William B. Inabnet,Steven K. Libutti,Andrew Arnold,Luca Lambertini,Micheal Stang,Herbert Chen,Yumi Kasai,Milind Mahajan,Yayoi Kinoshita,Gustavo Fernandez-Ranvier,Thomas C. Becker,Karen K. Takane,Laura Walker,Shira R Saul,Rong Chen,Rong Chen,Donald K. Scott,Jorge Ferrer,Yevgeniy Antipin,Yevgeniy Antipin,Michael J. Donovan,Andrew V. Uzilov,Andrew V. Uzilov,Boris Reva,Eric E. Schadt,Eric E. Schadt,Bojan Losic,Carmen Argmann,Andrew F. Stewart +33 more
TL;DR: It is shown at the pathway level that the majority of the insulinomas display mutations, copy number variants and/or dysregulation of epigenetic modifying genes, most prominently in the polycomb and trithorax families, revealing candidates for inducing beta cell regeneration.
Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells.
Hainan Chen,Jeffrey W. Kleinberger,Karen K. Takane,Fatimah Salim,Nathalie Fiaschi-Taesch,Kyrie Pappas,Ramon Parsons,Jing Jiang,Yue Zhang,Hongtao Liu,Peng Wang,Aaron Bender,Stuart J. Frank,Andrew F. Stewart +13 more
TL;DR: The findings show that human β-cells fail to proliferate in response to PRL for multiple reasons, one of which is a paucity of functional PRL receptors, and that murine Stat5 overexpression is able to bypass these impediments.
DYRK1A Inhibitors as Potential Therapeutics for β-Cell Regeneration for Diabetes.
Kunal Kumar,Chalada Suebsuwong,Peng Wang,Adolfo Garcia-Ocaña,Andrew F. Stewart,Robert J. DeVita +5 more
TL;DR: In this paper, the status of DYRK1A as a therapeutic target for β-cell proliferation is reviewed and perspectives on technical and scientific challenges for future translational development are provided.
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