Peng Gao
University of Hong Kong
26 Papers
17 Citations
Peng Gao is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Chemistry & Staphylococcus aureus. The author has an hindex of 8, co-authored 15 publications. Previous affiliations of Peng Gao include Li Ka Shing Faculty of Medicine, University of Hong Kong & Anhui Medical University.
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Papers
Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors.
Runming Wang,Tsz-Pui Lai,Peng Gao,Hongmin Zhang,Hongmin Zhang,Pak-Leung Ho,Pak-Leung Ho,Patrick C. Y. Woo,Patrick C. Y. Woo,Guixing Ma,Richard Y.T. Kao,Richard Y.T. Kao,Hongyan Li,Hongzhe Sun +13 more
TL;DR: The authors show that the anti-Helicobacter pylori drug colloidal bismuth subcitrate inhibits MBLs by displacing the zinc ions with Bi(III), which is of great interest for the development of antibiotics.
HKOCl-3: a fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and a 96-well microplate assay
Jun Jacob Hu,Nai-Kei Wong,Mingyang Lu,Xingmiao Chen,Sen Ye,Angela Qian Zhao,Peng Gao,Richard Y.T. Kao,Jiangang Shen,Dan Yang +9 more
TL;DR: An ultra-selective and ultra-sensitive HOCI fluorescent probe HKOCl-3 for live-cell and in vivo imaging and quantitative applications is described.
Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance.
Haibo Wang,Minji Wang,Minji Wang,Xiaohan Xu,Peng Gao,Zeling Xu,Qi Zhang,Hongyan Li,Aixin Yan,Richard Y.T. Kao,Hongzhe Sun +10 more
TL;DR: In this article, the authors identify 38 authentic Ag+-binding proteins in S. aureus at the whole-cell scale and further validate that Ag+ could inhibit a key target 6-phosphogluconate dehydrogenase through binding to catalytic His185 by X-ray crystallography.
Dehydrosqualene Desaturase as a Novel Target for Anti-Virulence Therapy against Staphylococcus aureus.
TL;DR: This study validates CrtN as a novel druggable target in S. aureus and presents a potent and effective lead compound for the development of virulence factor-based therapy against S.Aureus infections.
Methylation of Daptomycin Leading to the Discovery of Kynomycin, a Cyclic Lipodepsipeptide Active against Resistant Pathogens
Hoi Yee Chow,Kathy Hiu Laam Po,Kathy Hiu Laam Po,Peng Gao,Pilar Blasco,Xiukun Wang,Congran Li,Lianwei Ye,Kang Jin,Kaichao Chen,Edward Chan,Xuefu You,Richard Y.T. Kao,Sheng Chen,Xuechen Li +14 more
TL;DR: The improved antimicrobial activity of kynomycin was demonstrated in in vitro time killing assay, in vivo wax worm model and different mouse infection models, and showed the promise of the future design and development of next-generation daptomycin-based antibiotics.
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