Peng Chai
6 Papers
Peng Chai is an academic researcher. The author has contributed to research in topics: Cancer research & Glioma. The author has an hindex of 1, co-authored 1 publications.
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Papers
Lighting a Fire: Gasdermin-Mediated Pyroptosis Remodels the Glioma Microenvironment and Promotes Immune Checkpoint Blockade Response
Yonghua Cai,Kun Li,Jie Lin,X. J. Liang,Wei Xu,Zhengming Zhan,Shuaishuai Xue,Yu Zeng,Peng Chai,Yangqi Mao,Zi-Bin Song,Lei Han,Ye Song,Xian Zhang,Hai Wang +14 more
TL;DR: It is suggested that pyroptosis of glioma cells may perform the dual function of promoting both tumorigenesis and antitumor immunity.
Abstract 3037: RSK4 inhibition promotes pseudo-hypoxic metabolic responses in lung adenocarcinoma
Lucksamon Thamlikitkul,Peng Chai,Cristina Balcells Nadal,Raja Roy,Xiao-Ming Sun,Marion MacFarlane,Hector C. Keun,Michael J. Seckl,Olivier E. Pardo +8 more
TL;DR: RSK4 knockdown promotes a pseudo-hypoxic phenotype in lung adenocarcinoma cells characterized by increased glycolysis and enhanced glutamine utilization via reductive carboxylation and targeting these changes potentiates the effects of RSK4 inhibition.
Glioma cell membrane camouflaged cinobufotalin delivery system for combinatorial orthotopic glioblastoma therapy
Zi-Bin Song,Liqian Zhao,Weiyi Fang,Siyun Guo,Anqi Xu,Zhengming Zhan,Yonghua Cai,Shuaishuai Xue,Peng Chai,Qiuhua Jiang,Peng Zhao,Ye Song +11 more
TL;DR: The glioma cell membrane camouflaged nanocomposite of Cu2−xSe and cinobufotalin with its significant anti-glioma property and well biosafety will provide novel alternatives for clinical treatment of GBM.
GSE1 negative regulation by miR-489-5p promotes breast cancer cell proliferation and invasion.
TL;DR: Findings suggest that GSE1 may function as a novel oncogene in breast cancer and it can be regulated by miR-489-5p.
Optimization of cancer immunotherapy through pyroptosis: A pyroptosis-related signature predicts survival benefit and potential synergy for immunotherapy in glioma
Yu Zeng,Yonghua Cai,Peng Chai,Yangqi Mao,Yanwen Chen,Li Jun Wang,Kunlin Zeng,Z. Zhan,Yuxin Xie,Cuiying Li,Hongchao Zhan,Liqian Zhao,Xiaoxia Chen,Xiaoxia Zhu,Yu Liu,Ming Chen,Ye Song,Aidong Zhou +17 more
TL;DR: The correlation between the pyroptosis signature and the tumor immune microenvironment may be used to further guide the sensitization of glioma patients to immunotherapy.