Pekka T. Männistö
University of Helsinki
410 Papers
4.6K Citations
Pekka T. Männistö is an academic researcher from University of Helsinki. The author has contributed to research in topics: Catechol-O-methyl transferase & Dopamine. The author has an hindex of 54, co-authored 410 publications. Previous affiliations of Pekka T. Männistö include University of Oulu & Uppsala University.
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Papers
Hormone responses to sedative drugs and cold exposure in two rat lines with high and low alcohol sensitivity
TL;DR: The results confirm and extend the earlier findings of the inability of ANT rats to produce additional stress responses to behavioral challenges when being intoxicated by sedative drugs, which may at least partly account for their increased sensitivity to sedatives.
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The Toxicity of Two MAO Inhibitors Combined with 5‐HTP or L‐DOPA in Anaesthetized Mice
TL;DR: It is suggested that halothane decreases the toxicity of MAO-inhibitor + L-DOPA through a central action, possibly by reducing the body temperature of mice during the critical period.
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Production of functional recombinant tyrosine hydroxylase by the BPV-1 expression plasmids in the cell cultures.
Pasi Lampela,Marko Huotari,Anu Harjula,Lasse Oinonen,Mart Ustav,Seppo Ylä-Herttuala,Pekka T. Männistö,Atso Raasmaja +7 more
TL;DR: The aim of the present work was to examine the transfection of BPVTH plasmids to express a dopaminergic transgene in the monkey CV1-P fibroblast, rat C6 glioma and human NHA astrocyte cell cultures.
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Neuroendocrine Effects of Dexmedetomidine: Evidence of Cross‐Tolerance Between a μ‐Opioid Agonist and an α2‐Adrenoceptor Agonist in Growth Hormone Secretion of the Male Rat
TL;DR: There is a clear cross-tolerance between dexmedetomidine and morphine in growth hormone secretion of the rat, and adrenergic mechanisms are involved in the morphine-induced stimulation of growth hormones secretion, but not in the Morphine- induced stimulation of prolactin secretion.
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Development of tolerance to the hormonal effects of morphine without changes in the aminergic functions in the brain of the rat
Pekka Rauhala,Raimo K. Tuominen,Päivi Tuomainen,M. Toivonen,S. A. Borisenko,Pekka T. Männistö +5 more
TL;DR: The effect of morphine on cold-stimulated secretion of TSH and prolactin was studied in male rats, both in acute studies and after the chronic administration of morphine for 14 days.
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