Pekka T. Männistö
University of Helsinki
410 Papers
4.6K Citations
Pekka T. Männistö is an academic researcher from University of Helsinki. The author has contributed to research in topics: Catechol-O-methyl transferase & Dopamine. The author has an hindex of 54, co-authored 410 publications. Previous affiliations of Pekka T. Männistö include University of Oulu & Uppsala University.
Chat about Author
Papers
Reduced natriuretic response to acute sodium loading in COMT Gene deleted mice
Cecilia Odlind,Ilkka Reenilä,Pekka T. Männistö,Risto O. Juvonen,Staffan Uhlén,Joseph A. Gogos,Joseph A. Gogos,Maria Karayiorgou,Peter Hansell +8 more
TL;DR: The hypothesis that catechol-O-methyltransferase has an important role in the DA-mediated regulation of renal sodium excretion in mice with reduced or absent COMT activity is supported.
Effect of stress and dexamethasone on immunoreactive β‐endorphin levels in rat hypothalamus and pineal
TL;DR: The almost complete disappearance of beta-endorphin from the pineal in response to stress and dexamethasone suggests that pineal does not itself synthesize the hormone but only utilizes and/or stores it.
18
Comparative liver toxicity of various erythromycin derivatives in animals.
Matti Viluksela,Hannu Hanhijärvi,R. F. A. Husband,Veli-Matti Kosma,Y. Collan,Pekka T. Männistö +5 more
TL;DR: The dog proved to be a more sensitive model for assessing the hepatotoxicity of erythromycin derivatives and EC and EE were clearly hepatotoxic in dogs, and EC also in rats.
16
Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.
Elina M. Jarho,Erik A.A. Wallén,Johannes A. M. Christiaans,Markus M. Forsberg,Jarkko I. Venäläinen,Pekka T. Männistö,Jukka Gynther,Antti Poso +7 more
TL;DR: A series of dicarboxylic acid azacycle l-prolyl-pyrrolidine amides was synthesized, and their inhibitory activity against prolyl oligopeptidase (POP) from porcine brain was tested, finding two different binding modes that favors lipophilic structures and one that favors nonhydrophobic structures.
16
Pharmacokinetic interactions of timolol with vasodilating drugs, food and phenobarbitone in healthy human volunteers
TL;DR: It is concluded that the pharmacokinetics of timolol maleate can be altered to a limited extent in opposite directions by dihydralazine and phenobarbitone.
16