Pei Wang
Nanjing University
23 Papers
23 Citations
Pei Wang is an academic researcher from Nanjing University. The author has contributed to research in topics: Biology & Myosin light-chain kinase. The author has an hindex of 10, co-authored 19 publications.
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Papers
Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism.
Chen Chen,Tao Tao,Cheng Wen,Wei-Qi He,Yan-Ning Qiao,Yun-Qian Gao,Xin Chen,Pei Wang,Cai-Ping Chen,Wei Zhao,Hua-Qun Chen,An-Pei Ye,Yajing Peng,Min-Sheng Zhu,Min-Sheng Zhu +14 more
TL;DR: It is suggested that MLCK is not required for myosin phosphorylation in a migrating cell, thereby stabilizing the membrane skeleton through F-actin-binding activity and shed light on a novel regulatory mechanism of protrusion during cell migration.
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Altered Contractile Phenotypes of Intestinal Smooth Muscle in Mice Deficient in Myosin Phosphatase Target Subunit 1
Wei-Qi He,Yan Ning Qiao,Yajing Peng,Juan Min Zha,Cheng-Hai Zhang,Chen Chen,Cai Ping Chen,Pei Wang,Xiao Yang,Chao-Jun Li,Kristine E. Kamm,James T. Stull,Min-Sheng Zhu,Min-Sheng Zhu +13 more
TL;DR: Myosin light chain phosphatase is not essential for smooth muscle function in mice but regulates the Ca(2+) sensitivity of force development and contributes to intestinal phasic contractile phenotype.
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Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension
Wei-Qi He,Wei-Qi He,Yan Ning Qiao,Cheng-Hai Zhang,Yajing Peng,Chen Chen,Pei Wang,Yun Qian Gao,Cai-Ping Chen,Xin Chen,Tao Tao,Xiao Hong Su,Chao-Jun Li,Kristine E. Kamm,James T. Stull,Min-Sheng Zhu,Min-Sheng Zhu +16 more
TL;DR: It is suggested that MLCK and its phosphorylation of RLC are required for tonic VSM contraction, and mice with smooth muscle-specific knockout of M LCK exhibit significantly lower basal blood pressure and weaker responses to vasopressors.
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In vivo roles for myosin phosphatase targeting subunit‐1 phosphorylation sites T694 and T852 in bladder smooth muscle contraction
Cai Ping Chen,Xin Chen,Yan Ning Qiao,Pei Wang,Wei-Qi He,Cheng-Hai Zhang,Wei Zhao,Yun Qian Gao,Chen Chen,Tao Tao,Jie Sun,Ye Wang,Ning Gao,Kristine E. Kamm,James T. Stull,Min-Sheng Zhu +15 more
TL;DR: Phosphorylation of MYPT1 T694, but not T852, mediates force maintenance via inhibition of MLCP activity and enhancement of RLC phosphorylation in vivo in regulation of smooth muscle contraction.
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Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance.
Yun-Qian Gao,Xin Chen,Pei Wang,Lei Lu,Wei Zhao,Chen Chen,Cai-Ping Chen,Tao Tao,Jie Sun,Yan-Yan Zheng,Jie Du,Chao-Jun Li,Zhenji Gan,Xiang Gao,Hua-Qun Chen,Min-Sheng Zhu +15 more
TL;DR: The results showed that the maternally expressed miR-379/miR-544 cluster might regulate skeletal muscle growth through the imprinted Delta-like 1 homolog (Dlk1) gene in mice, revealing a molecular mechanism of the polar overdominance inheritance.
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