Peggy Engelhard
University of Freiburg
6 Papers
Peggy Engelhard is an academic researcher from University of Freiburg. The author has contributed to research in topics: Innate immune system & Inflammation. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Peggy Engelhard include University Medical Center Freiburg.
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Papers
Nontransformed, GM-CSF–dependent macrophage lines are a unique model to study tissue macrophage functions
György Fejer,Mareike Dorothee Wegner,Ildiko Györy,Idan Cohen,Peggy Engelhard,Elena Voronov,Thomas Manke,Zsolt Ruzsics,Lars Dölken,Olivia Prazeres da Costa,Nora Branzk,Michael Huber,Antje Prasse,Robert Schneider,Ron N. Apte,Chris Galanos,Marina A. Freudenberg +16 more
TL;DR: The generation of nontransformed murine macrophages is reported, which are similar to alveolar Macrophages and can be grown continuously without change of phenotype and in unlimited amounts, and offer an useful tool to study macrophage biology and for biomedical science.
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Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages.
Mareike D. Maler,Mareike D. Maler,Peter J. Nielsen,Nicole Stichling,Idan Cohen,Zsolt Ruzsics,Connor Wood,Peggy Engelhard,Maarit Suomalainen,Ildiko Gyory,Michael Huber,Joachim Müller-Quernheim,Wolfgang W. A. Schamel,Siamon Gordon,Thilo Jakob,Stefan F. Martin,Willi Jahnen-Dechent,Urs F. Greber,Marina A. Freudenberg,Marina A. Freudenberg,György Fejer,György Fejer +21 more
TL;DR: It is shown that adenovirus infection is significantly more efficient in MARCO-positive alveolar macrophages and in AM-like primary macrophage lines (Max Planck Institute cells) than in MARco-negative bone marrow-derived macrophAGE lines.
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The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation.
Christine Huppertz,Benedikt Jäger,Grazyna Wieczorek,Peggy Engelhard,Peggy Engelhard,Stephen John Oliver,Franz-Georg Bauernfeind,Amanda Littlewood-Evans,Tobias Welte,Veit Hornung,Antje Prasse +10 more
TL;DR: Evidence of upregulated inflammasome and IL-1β pathway activation in sarcoidosis is provided and both as valid therapeutic targets are suggested.
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Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro
Jonas C. Schupp,Sandrine Tchaptchet,Niklas Lützen,Peggy Engelhard,Joachim Müller-Quernheim,Marina A. Freudenberg,Marina A. Freudenberg,Antje Prasse +7 more
TL;DR: Patients with sarcoidosis had elevated levels of specific antibodies against P. acnes which suggest contact with this bacterium in the past, and inflammatory cytokines (TNF-α and GM-CSF) upon stimulation with P. Acnes indicated potential involvement of this pathogen in the pathogenesis of sarcoIDosis in some patients.
Airway Basal Cells show a dedifferentiated KRT17highPhenotype and promote Fibrosis in Idiopathic Pulmonary Fibrosis
Benedikt Jaeger,Jonas C. Schupp,Linda Plappert,Oliver Terwolbeck,Gian Kayser,Peggy Engelhard,Taylor Adams,Robert Zweigerdt,Henning Kempf,Stefan Lienenklaus,Wiebke Garrels,Irina Nazarenko,Irina Nazarenko,Danny Jonigk,Malgorzata Wygrecka,Denise Klatt,Axel Schambach,Axel Schambach,Naftali Kaminski,Antje Prasse +19 more
TL;DR: Saracatinib modified in-vitro and in- vivo the profibrotic changes observed in the 3D culture system and novel mouse xenograft model, and demonstrated that gene expression changes in IPF-ABC can be reversed by SRC inhibition.