Peedikayil E. Thomas
University of Michigan
31 Papers
508 Citations
Peedikayil E. Thomas is an academic researcher from University of Michigan. The author has contributed to research in topics: Enhancer & Mutation. The author has an hindex of 17, co-authored 30 publications.
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Papers
Myofibroblast Differentiation by Transforming Growth Factor-β1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase
Victor J. Thannickal,Daniel Y. Lee,Eric S. White,Zongbin Cui,Jose M. Larios,Raquel Chacon,Jeffrey C. Horowitz,Regina M. Day,Peedikayil E. Thomas +8 more
TL;DR: It is demonstrated that stable expression of the myofibroblast phenotype requires both TGF-β1 and adhesion-dependent signals, and a safer and more effective therapeutic strategy for fibrotic diseases characterized by persistent myofIBroblast activation may be to target this integrin/FAK pathway while not interfering with tumor-suppressive functions of TGF -β1/Smad signaling.
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MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1.
Guozhi Xiao,Di Jiang,Peedikayil E. Thomas,M. Douglas Benson,Kun-Liang Guan,Gerard Karsenty,Renny T. Franceschi +6 more
TL;DR: This study is the first demonstration that Cbfa1 is controlled by MAPKs and suggests that this pathway has an important role in the control of osteoblast-specific gene expression.
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GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit.
Peedikayil E. Thomas,Bryan L. Wharram,Meera Goyal,Jocelyn Wiggins,Lawrence B. Holzman,Roger C. Wiggins +5 more
TL;DR: It is expected that this receptor might play a role in maintaining foot process structure and/or function by regulating tyrosine phosphorylation of podocyte proteins by analogy with the CD45 PTPase of T cells.
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Molecular Cloning and Characterization of Human Podocalyxin-like Protein ORTHOLOGOUS RELATIONSHIP TO RABBIT PCLP1 AND RAT PODOCALYXIN
David B. Kershaw,Stephen G. Beck,Bryan L. Wharram,Jocelyn Wiggins,Meera Goyal,Peedikayil E. Thomas,Roger C. Wiggins +6 more
TL;DR: It is concluded that this cDNA and putative peptide represent the human homolog of rabbit PCLP1 and rat podocalyxin.
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Identification of a homeodomain binding element in the bone sialoprotein gene promoter that is required for its osteoblast-selective expression.
M. Douglas Benson,Jeffrey L. Bargeon,Guozhi Xiao,Peedikayil E. Thomas,Ahn Kim,Yingqi Cui,Renny T. Franceschi +6 more
TL;DR: It is found that the Dlx5 homeoprotein, which is able to regulate the osteoblast-specific osteocalcin promoter, can bind this element and stimulate its enhancer activity when overexpressed in COS7 cells.
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