Payal Ray
Northwestern University
8 Papers
3 Citations
Payal Ray is an academic researcher from Northwestern University. The author has contributed to research in topics: RNA splicing & Alternative splicing. The author has an hindex of 6, co-authored 8 publications.
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Papers
An ALS-associated Mutation Affecting TDP-43 Enhances Protein Aggregation, Fibril Formation and Neurotoxicity
Weirui Guo,Yanbo Chen,Xiaohong Zhou,Amar N. Kar,Amar N. Kar,Payal Ray,Xiaoping Chen,Elizabeth J. Rao,Mengxue Yang,Haihong Ye,Li Zhu,Jianghong Liu,Meng Xu,Yanlian Yang,Chen Wang,David Luowei Zhang,Eileen H. Bigio,M.-Marsel Mesulam,Yan Shen,Qi Xu,Kazuo Fushimi,Jane Y. Wu +21 more
TL;DR: Comparing wild-type and an ALS-associated mutant TDP-43 in vitro and in vivo provides evidence for biochemical similarities between TPD-43 and prion proteins, raising the possibility that T DP-43 derivatives may cause spreading of the disease phenotype among neighboring neurons.
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A Drosophila model for TDP-43 proteinopathy
Yan Li,Payal Ray,Elizabeth J. Rao,Chen Shi,Chen Shi,Weirui Guo,Xiaoping Chen,Elvin A. Woodruff,Kazuo Fushimi,Jane Y. Wu +9 more
TL;DR: Transgenic flies expressing hTDP-43 recapitulate important neuropathological and clinical features of human TDP- 43 proteinopathy, providing a powerful animal model for this group of devastating diseases.
The splicing factor Prp31 is essential for photoreceptor development in Drosophila
TL;DR: Sequence analyses show that CG6876 is the likely candidate of Drosophila melanogaster Prp31 homolog (DmPrp31), and predicted peptide sequence forCG6876 shows 57% similarity to the Homo sapiens Prp 31 protein (HsPrp 31).
Alternative Pre-mRNA Splicing, Cell Death, and Cancer
Kong Ruirui,Payal Ray,Mengxue Yang,Pushuai Wen,Li Zhu,Jianghong Liu,Kazuo Fushimi,Amar N. Kar,Ying Liu,Rongqiao He,David Kuo,Jane Y. Wu +11 more
TL;DR: A global picture of the complex mechanisms that regulate cell death genes at the pre-mRNA splicing level has thus begun to emerge.
3
RNA Helicase p68 (DDX5) Regulates tau Exon 10 Splicing by Modulating a Stem-Loop Structure at the 5′ Splice Site
Amar N. Kar,Kazuo Fushimi,Xiaohong Zhou,Payal Ray,Chen Shi,Xiaoping Chen,Zhiren Liu,She Chen,Jane Y. Wu +8 more
TL;DR: This study reports the first RNA helicase interacting with a stem-loop structure at the splice site and regulating alternative splicing in a helicase-dependent manner and uncovers a previously unknown function of p68 in regulating tau exon 10 splicing.